NCT06068335招募中不适用
Innate Immunity in Allergic Asthma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To determine which parameters of the established type-2 signature obtained in vitro is significantly different between healthy controls, allergic individuals, and asthmatic individuals ex vivo.
研究概览
简要总结
The purpose of this study is to determine whether a potential type 2 signature, obtained through stimulation of cell lines with various allergens in vitro, correlates with an allergic or asthmatic disease state ex vivo. This type 2 signature will be multi-hierarchical in nature and will be comprised cell surface receptor expression, pathway activation, and gene upregulation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants must be at least 18 years of age
- •no history of allergic disease (healthy controls), have clinically diagnosed allergies, or have clinically diagnosed asthma.
排除标准
- •Pregnant women and prisoners will be excluded from the study.
- •Individuals currently suffering from any acute infections and those known to suffer from light-headedness will be excluded.
结局指标
主要结局
To determine which parameters of the established type-2 signature obtained in vitro is significantly different between healthy controls, allergic individuals, and asthmatic individuals ex vivo.
时间窗: 1 year
次要结局
- To determine ex vivo whether any of the identified disease-specific type-2 parameters can be modified (brought back to healthy control levels) through the use of investigational compounds.(1 year)
研究者
研究点 (1)
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