Innate Immunity in Allergic Asthma
Recruiting
- Conditions
- Asthma
- Registration Number
- NCT06068335
- Lead Sponsor
- University of Central Florida
- Brief Summary
The purpose of this study is to determine whether a potential type 2 signature, obtained through stimulation of cell lines with various allergens in vitro, correlates with an allergic or asthmatic disease state ex vivo. This type 2 signature will be multi-hierarchical in nature and will be comprised cell surface receptor expression, pathway activation, and gene upregulation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Participants must be at least 18 years of age
- no history of allergic disease (healthy controls), have clinically diagnosed allergies, or have clinically diagnosed asthma.
Exclusion Criteria
- Pregnant women and prisoners will be excluded from the study.
- Individuals currently suffering from any acute infections and those known to suffer from light-headedness will be excluded.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine which parameters of the established type-2 signature obtained in vitro is significantly different between healthy controls, allergic individuals, and asthmatic individuals ex vivo. 1 year
- Secondary Outcome Measures
Name Time Method To determine ex vivo whether any of the identified disease-specific type-2 parameters can be modified (brought back to healthy control levels) through the use of investigational compounds. 1 year
Trial Locations
- Locations (1)
University of Central Florida
🇺🇸Orlando, Florida, United States