Bone Mineral Density and Markers of Bone Turnover After Roux-en-Y Gastric Bypass
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Changes in bone mineral density of non-weight bearing bone
研究概览
简要总结
Bone mineral density (BMD) is decreased after Roux-en-Y gastric bypass (RYGB) but whether RYGB induces changes in BMD beyond adaptation to major weight loss is not known. We aim to investigate BMD changes in weight bearing (hip, lumbal columna) and in non-weight bearing (forearm) regions before and after maximal weight loss at 1 year and after weight stabilisation at 4 years after RYGB. Moreover, plasma markers of bone turnover will be studied at fasting and during oral glucose tolerance test.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participation in previos study ((NCT 01202526)
排除标准
- •Treatment of osteoporosis
结局指标
主要结局
Changes in bone mineral density of non-weight bearing bone
时间窗: 1 year, 4 years
DXA scans of forearm
Changes in bone mineral density of weightbearing bone
时间窗: 1 year, 4 years
DXA scans of hip and lumbal columna
次要结局
- Plasma markers of bone turnover(3 months, 1 year, 4 years)
研究者
Kirstine Nyvold Bojsen-Moeller
MD, PhD
Hvidovre University Hospital