CLINICAL EVALUATION OF THE EFFECTIVENESS OF A LEUCO-LIPID FILTER APPLIED TO INTRA-OPERATIVE CARDIOTOMY SUCTION IN PATIENTS SUBJECTED TO EXTRACORPOREAL CIRCULATION.
Recruiting
- Conditions
- Three groups of 50 patients, scheduled for myocardial revascularization surgery with the use of cardiopulmonary bypass.
- Registration Number
- NL-OMON28768
- Lead Sponsor
- niversity Hospital BrusselsLaarbeeklaan 1011090 Brussel
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
All patients admitted for coronary artery bypass grafting surgery. A clinical consideration will be taken over the patient’s blood loss. If blood loss is low, it will be discarded. If blood loss is significant for patients blood balance, the volume will be added to the circulation. The filter used for filtration will contain a leuco-lipid filter or contain a standard filter.
Exclusion Criteria
1. Repeated surgery;
2. Requirement for dialysis;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical evaluation of a filter for the removal of lipid particles and leukocytes from mediastinal suctioned blood during cardiopulmonary bypass (CPB).
- Secondary Outcome Measures
Name Time Method 1. Does filtration of the lipid particles reduce the inflammatory response to CPB?<br /><br>2. Evaluation of the capacity of removing white blood cells from suction blood by cardiotomy filtration;<br /><br>3. Research on possible adverse effects that the filter may have on blood rheology (increased haemolysis, drop in platelets, etc.);<br /><br>4. Does the decrease of inflammatory response and a lower lipid micro emboli level have any clinical impact (in particular, the myocardial, pulmonary, renal and neurological functions are to be evaluated)?