Correlation of Albuminuria With Arterial Stiffness

Completed

• Conditions: Diabetes Mellitus; Hypertension; Vascular Stiffness; Albuminuria

• Registration Number: NCT01041599
• Lead Sponsor: Istanbul University

Brief Summary

The investigators aim to investigate the relationship between albuminuria and arterial stiffness in diabetic patients, hypertensive patients and healthy subjects.

Detailed Description

CONTEXT: Albuminuria is an important cardiovascular risk factor. Arterial stiffness also gives important information about atherosclerosis. Oscillometric methods may be useful in assessing arterial stiffness in a mainly operator independent way.

OBJECTIVE: We aim to investigate the relationship between albuminuria and arterial stiffness measured with an oscillometric device in diabetic patients, hypertensive patients and healthy subjects.

METHODS: 152 diabetic patients, 152 hypertensive patients and 152 healthy subjects are planned to be enrolled in this study. The measurements will be done between 9:00 and 13:00. After the measurements, blood and urine samples will be obtained, centrifugated and kept in -80°C until assayed. Afterwards, echocardiographic left ventricle mass index will be calculated. The correlation between albuminuria and arterial stiffness will be assessed as the primary outcome measure.

Study Timeline

• Study Start: 2009-10
• Study First Submitted: 2009-12-30
• Study First Submitted QC: 2009-12-31
• Study First Posted: 2010-01-01
• Primary Completion: 2011-12
• Study Completion: 2012-02
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-29
• Last Update Posted: 2016-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 152

Inclusion Criteria

• Diabetes Mellitus
• Hypertension
• Healthy subjects

Exclusion Criteria

• Symptomatic cardiovascular diseases (heart failure, history of myocardial infarction, etc.)
• Renal failure
• Pregnancy
• Diseases of the aorta

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between albuminuria and arterial stiffness	Albuminuria and arterial stiffness will be assessed simultaneously (i.e. in the same morning)

Trial Locations

Locations (1)

Istanbul Univesity Istanbul Medical Faculty Department of Internal Medicine; 🇹🇷 Istanbul, Turkey