Effect of local desmopressin administration on intraoperative blood loss and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis.

Phase 3

• Conditions: Chronic rhinosinusitis.; Chronic pansinusitis

• Registration Number: IRCT20130713013976N5
• Lead Sponsor: Hamedan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 May 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

Suffering from chronic rhinosinusitis with or without polyposis
Between 18 to 60 years old
Normal coagulative tests and platelet count

Exclusion Criteria

Suffering from coagulative disorders like Hemophilia
Suffering from sinunasal tumors
History of thromboembolic accident
Suffering from acute or chronic renal failure
Receiving Heparin in 48 hour before surgery
Receiving Aspirin in 3 days before surgery
Allergy to Desmopressin
Liver scirrhosis
Systemic diseases like hypertension, diabet mellitus, heart failure
Pregnancy
Cardiac stent

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Visual field of surgery. Timepoint: 15,30,60,90 minutes after starting surgery. Method of measurement: Boezaart Grading.;Bleeding volume. Timepoint: 15,30,60,90 minutes after starting surgery. Method of measurement: blood volume in suction s bottle.

Secondary Outcome Measures

Name	Time	Method
Mean arterial pressure. Timepoint: before and in points of 15,30,60 and 90 min after surgery. Method of measurement: blood pressure monitoring.;Surgery duration. Timepoint: time of starting upto end of the surgery. Method of measurement: recording duration of surgery.;Serum sodiume level. Timepoint: before and after the surgery. Method of measurement: serum sodiume level test.