Intravenous Desmopressin, Tranexamic Acid, and Their Combined Impact on Intra-Operative Bleeding in Functional Endoscopic Sinus Surgery
- Conditions
- Condition 1: Chronic sinusitis. Condition 2: Nasal polyp.Chronic sinusitisNasal polyp
- Registration Number
- IRCT20231112060028N1
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 93
First-time candidates of bilateral FESS due to chronic rhinosinusitis with polyp
Patients should have a normal test result (CBC, PT, PTT, renal function tests, electrolytes)
Patients classified as American Society of Anesthesiologists (ASA) I and ASA II
Wegener's disease
Sarcoidosis
Sinonasal malignancy
Bleeding disorders
Known hypersensitivity to TXA or DDAVP
Active venous or arterial thromboembolic disease
History of seizures
Renal impairment (defined as a creatinine clearance below 50 mL/min)
Disseminated Intravascular Coagulation (DIC) or any coagulopathy
Color vision disorders
Pregnancy and breastfeeding
Heart failure or other conditions needing fluid restrictions
Hyponatremia or history of hyponatremia
Revision surgeries
Poorly controlled hypertension or cerebrovascular disease
History of significant coronary artery disease or arrhythmias
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intra-operative blood loss. Timepoint: Intra-operative and at the end of the operation. Method of measurement: The volume of blood suctioned during the operation excluding the normal volume of saline used.;Surgical field bleeding score. Timepoint: Intraoperative. Method of measurement: BOEZAART grading scale for scoring surgical field bleeding.
- Secondary Outcome Measures
Name Time Method Duration of surgery. Timepoint: At the end of the operation. Method of measurement: The end of the operation minus the start of the operation.