Comparison of Platelet Rich in growth factor and Hyaluronic acid in patients with knee osteoarthritis
- Conditions
- Knee osteoarthritis (Gonarthrosis).Gonarthrosis [arthrosis of knee]
- Registration Number
- IRCT2016071513442N11
- Lead Sponsor
- Physical Medicine and Rehabilitation Department of Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
arthralgia since the past 3 months; radiologic evidence of articular damage (grade 2,3 of Kellgren-Lawrence scale) based on knee OA criteria of ACR. Exclusion criteria: systemic diseases such as diabetes mellitus and collagen vascular disorders; history or presence of cancer or malignant disorders; any infection and active wound of the knee; presence of immunosuppressive, autoimmune and platelet disorders; treatment with anticoagulant and anti-platelet medications 10 days before injection; use of NSAIDs 2 days before injection; history of knee articular injections of corticosteroids 3 weeks or use of systemic corticosteroids 2 weeks before PRP injections; hemoglobin measures of less than 12 g/dl and platelet counts of less than 150,000 per micro liter; recent history of severe trauma to the knee; age less than 45 or over 75 year; history of vasovagal shock; pregnancy; breastfeeding; genu valgum/varum greater than 20 degrees.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Knee pain. Timepoint: before intervention, 2 months & 6 months after intervention. Method of measurement: WOMAC questionnaire.;Function. Timepoint: before intervention, 2 months & 6 months after intervention. Method of measurement: WOMAC questionnaire.;The maximum distance of walking. Timepoint: before intervention, 2 months & 6 months after intervention. Method of measurement: Lequesne Index.;Activity of daily living. Timepoint: before intervention, 2 months & 6 months after intervention. Method of measurement: Lequesne Index.;Joint Stiffness. Timepoint: before intervention, 2 months & 6 months after intervention. Method of measurement: WOMAC questionnaire.
- Secondary Outcome Measures
Name Time Method