Raspberry Ketone Intake Upregulates Circulating FGF21 and Induces Energy Expenditure in Humans

Early Phase 1

Completed

• Conditions: Obesity; Diabetes; NAFLD (Nonalcoholic Fatty Liver Disease)

• Registration Number: NCT06681597

Brief Summary

To investigate the molecular mechanism of raspberry ketone on regulating obesity, the investigators studied the effect of raspberry ketone intake on FGF21 in plasma.

The age of the volunteers were 18-60 years old, both male and female, without diabetes, hypertension and other diseases.

After ingestion of raspberry ketone (500mg), 2ml of blood was collected at 0 hours, 3 hours and 6 hours , and the FGF21 content in plasma was measured using a commercial reagent kit.

In addition, the investigators also studied the effect of raspberry ketone intake on energy metabolism 0 hours, 0.5 hours, 3 hours and 6 hours after consuming raspberry ketone (500mg).

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-11
• Study Start: 2024-01-10
• Primary Completion: 2024-05-15
• Study Completion: 2024-06-01
• Study First Submitted: 2024-11-02
• Study First Submitted QC: 2024-11-07
• Last Update Submitted: 2024-11-07
• Study First Posted: 2024-11-08
• Last Update Posted: 2024-11-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

No drugs were taken before the human study

Exclusion Criteria

Patients with hypertension

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Impact of raspberry ketone consumption on plasma FGF21 level	Through study completion, an average of 1 year
Impact of raspberry ketone consumption on energy expenditure	Through study completion, an average of 1 year	The oxygen consumption, heart rate, carbon dioxide production were measured