CTRI/2024/04/066229尚未招募不适用
Comparison 0f pretreatment with magnesium sulphate versus lignocaine on intense neuromuscular blockade of rocuronium in elective surgeries: a randomized control trial
未提供1 个研究点 分布在 1 个国家目标入组 54 人开始时间: 2024年5月5日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- ONSET OF NEUROMUSCULAR BLOCKADE OF ROCURONIUM
研究概览
简要总结
Both Magnesium Sulphate and Lignocaine have been proven to reduce the onset time of neuromuscular blockade of rocuronium as well as reduce the hemodynamic responses during laryngoscopy. Therefore, in this study, we aim to compare these two drugs to discover a more potent adjuvant for rocurnium between magnesium and lignocaine so that the dose of neuromuscular agent rocuronium can be reduced to avoid post operative residual neuromuscular paralysis
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Double
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •American Society Of Anaesthesiologist (ASA) grading 1-2
- •BMI 18.5-29.9
- •All GA Surgeries lasting for more than 2 hrs.
排除标准
- •1.Refused To Participate In The Study 2.Cardiac Conduction Abnormalities 3.Patients Having Neuromuscular Disease 4.known hepatic and renal dysfunction 5.Allergies to study drugs 6.Patients having electrolyte abnormalities 7.Patients on medications known to alter neuromuscular function 8.Patients having expected difficult mask ventilation or difficult laryngoscopy and intubation 9.Pregnant women.
结局指标
主要结局
ONSET OF NEUROMUSCULAR BLOCKADE OF ROCURONIUM
时间窗: From the time of giving rocurnium to the time of achieving T1(first twitch) less than or equal to 5%
次要结局
- HEMODYNAMIC RESPONSE TO LARYNGOSCOPY(Just before intubation, during laryngoscopy, just after intubation, 5 mins after intubation)
- time of first top-up dose of rocuronium(TOF Count 2-3)
- Total cumulative dose of Rocuronium(At the end of last top-up dose)
- Time of neuromuscular recovery(TOF ratio more than or equal to 0.9)
研究者
Dr Arhan Pasha
All India Institute of Medical Sciences, Rishikesh
研究点 (1)
Loading locations...
相似试验
尚未招募
2 期
Comparison of effects of two drugs on intracranial pressure in adults undergoing elective laparoscopic and robotic surgeryCTRI/2024/10/075369Jawaharlal Institute of Postgraduate Medical Education and Research108
尚未招募
不适用
Study of effect of an adjuvant to local anaesthetics in ultrasound guided supraclavicular brachial plexus block in upper limb surgeriesCTRI/2024/08/072932Shri Lal Bahadur Shastri Govt medical college Department of Anaesthesiology62
尚未招募
4 期
To compare the effect of two adjuvant drugs via regional anaesthesia in patients undergoing upper limb surgeriesCTRI/2025/04/085255Sabyasachi Mohapatra60
尚未招募
3 期
Comparing the Effect of drug Magnesium Sulphate with Bupivacaine versus Dexmedetomidine with Bupivacaine versus plain Bupivacaine in nerve block to relive postoperative pain in LSCS patients. The main outcome of the study is to compare the duration and effect of pain relief.CTRI/2025/04/084622Bhaarath medical college90
尚未招募
不适用
Comparing Magnesium and Ketamine to Prevent Muscle Twitches and Pain After Succinylcholine in Patients Undergoing SurgeryCTRI/2025/08/092279SRMS IMS128