Elevated Lipoprotein(a) in Hospital Staff

Recruiting

• Conditions: Hypercholesterolemia; Cardiovascular Diseases; Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia

• Registration Number: NCT06304415
• Lead Sponsor: Changi General Hospital

Brief Summary

The objective of this study is to investigate the prevalence of elevated Lp(a) in the working general population.

Detailed Description

The objective of this study is to investigate the prevalence of elevated lipoprotein(a) concentrations and distribution of lipoprotein(a) in a working general population. This is a prospective study investigating the association of lipoprotein(a) with cardiovascular markers and outcomes.

Study Timeline

• Study First Submitted: 2024-03-05
• Study First Submitted QC: 2024-03-05
• Study First Posted: 2024-03-12
• Study Start: 2024-04-01
• Status Verified: 2024-08
• Last Update Submitted: 2025-03-05
• Last Update Posted: 2025-03-07
• Primary Completion: 2035-12-01
• Study Completion: 2036-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2800

Inclusion Criteria

1. Any healthcare workers working in healthcare settings (regardless of PHI and/or private setting) aged 21 and above OR family member such as father, mother, siblings, grandparents, spouse and children aged 12 and above of recruited staff with high Lpa ≥120nmol/l
2. Study team members can also be recruited because we are trying to find the prevalence of elevated Lp(a)

Exclusion Criteria

1. Inability to provide informed consent.
2. Pregnant women.
3. Prisoner

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Distribution and prevalence of elevated Lipoprotein(a)	3 years	Investigate the distribution lipoprotein(a) and prevalence of elevated lipoprotein(a) concentrations in various ethnicities.

Secondary Outcome Measures

Name	Time	Method
Correlation of lipoprotein(a) with cardiovascular outcomes	10 years	Observational study to assess the correlation of degree of elevation of lipoprotein(a) with cardiovascular outcomes prospectively.
Genetic variants of lipoprotein(a) and cardiovascular outcomes atherosclerotic events	10 years	Assess the association of genetic variants of lipoprotein(a) with the measured lipoprotein(a) concentrations in various ethnicities, and prospectively assess the association of these genetic variants with cardiovascular outcomes

Trial Locations

Locations (1)

Clinical Trials & Research Unit; 🇸🇬 Singapore, Singapore