Exercise and Arterial Modulation in Youth
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiovascular Disease
- Sponsor
- University of Basel
- Enrollment
- 337
- Locations
- 1
- Primary Endpoint
- Association of arterial stiffness (pulse wave velocity) with physical fitness in primary school children
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The project is designed as a large scale, cross-sectional study. The aim of the study is to investigate the association of micro- and macrovascular function with physical fitness and body composition in primary school children.
Detailed Description
The investigators will examine whether physical fitness, body composition and blood pressure differently affect large and small arteries in young children. Furthermore, the investigators will examine whether pulmonary dysfunction is associated with vascular disorders and if subcutaneous advanced glycation endproducts (AGE's) mediate some of the vascular alterations observed.
Investigators
Henner Hanssen
Prof.Dr.med. Henner Hanssen
University of Basel
Eligibility Criteria
Inclusion Criteria
- •primary school children aged 6-8 years who can participate in physical education lessons with written consent from their parents.
Exclusion Criteria
- •children with a medical certificate that prohibits physical exercise with no consent from their parents.
Outcomes
Primary Outcomes
Association of arterial stiffness (pulse wave velocity) with physical fitness in primary school children
Time Frame: Through study completion, an average of 1 year.
Oscillometric calculation of central pulse wave velocity.
Secondary Outcomes
- Association of lung function (FEV1/VC) with body composition, blood pressure and physical fitness(Through study completion, an average of one year.)
- Association of arteriolar-to-venular diameter ratio (AVR) with physical fitness in primary school children(Through study completion, an average of 1 year.)
- Association of subcutaneous advanced glycation endproducts (AGEs) with body composition, blood pressure and physical fitness(Through study completion, an average of one year.)