The correlation between low coagulation factor XIII activity and anastomotic leakage in patients who undergo bowel resection: a prospective observational study
- Conditions
- K91.83
- Registration Number
- DRKS00015021
- Lead Sponsor
- Medizinische Universität Wien
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting stopped after recruiting started
- Sex
- All
- Target Recruitment
- 338
Inclusion Criteria
Patients, male or female, older than 18 years, receiving a bowel resection with anastomosis or stump
Exclusion Criteria
Pre-existing coagulopathy (hemophilia, factor V Leiden mutation, protein C deficiency, protein S deficiency, antiphospholipid syndrome)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Anastomotic leakage: yes/no
- Secondary Outcome Measures
Name Time Method Incidence of anastomotic leakages
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link coagulation factor XIII deficiency to anastomotic leakage in K91.83 post-bowel resection patients?
How does preoperative factor XIII activity compare to standard-of-care risk factors for predicting anastomotic leakage in DRKS00015021?
Are fibrinogen cross-linking biomarkers (e.g., factor XIIIa) reliable indicators for anastomotic healing outcomes in colorectal surgery?
What adverse events are associated with low factor XIII levels in bowel resection patients, and how are they managed clinically?
Which coagulation factor XIII modulators or combination therapies show promise in preventing anastomotic leakage in gastrointestinal surgery?