MedPath

Cabozantinib-S-Malate in Treating Patients With Recurrent or Progressive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Phase 2
Completed
Conditions
Fallopian Tube Clear Cell Adenocarcinoma
Ovarian Clear Cell Adenocarcinoma
Recurrent Fallopian Tube Carcinoma
Recurrent Ovarian Carcinoma
Recurrent Primary Peritoneal Carcinoma
Interventions
Drug: Cabozantinib S-malate
Other: Laboratory Biomarker Analysis
Registration Number
NCT02315430
Lead Sponsor
National Cancer Institute (NCI)
Brief Summary

This phase II trial studies how well cabozantinib-s-malate works in treating patients with ovarian, fallopian tube, or primary peritoneal cavity cancer that has come back or is growing, spreading, or getting worse. Cabozantinib-s-malate may stop the growth of tumor cells by blocking the growth of new blood vessels necessary for tumor growth and also by blocking some of the enzymes needed for cell growth.

Detailed Description

PRIMARY OBJECTIVES:

I. To evaluate the anti-tumor activity of cabozantinib (XL184) (cabozantinib-s-malate) in women with persistent or recurrent clear cell ovarian cancer, based on the proportion of patients who survive progression-free for at least 6 months and the proportion who have objective tumor response (complete or partial).

SECONDARY OBJECTIVES:

I. To determine the nature, frequency and maximum degree of toxicity as assessed by Common Terminology Criteria for Adverse Events (CTCAE) version (v)4 for cabozantinib (XL184).

II. To determine the progression free survival (PFS) and overall survival (OS) for patients with persistent or recurrent clear cell ovarian cancer treated with cabozantinib (XL184).

TERTIARY OBJECTIVES:

I. To examine the expression of phosphatase and tensin homolog gene (PTEN), phosphorylated v-akt murine thymoma viral oncogene homolog 1 (pAKT), cyclin E, and met proto-oncogene (MET) in formalin-fixed, paraffin-embedded tumor.

II. To examine MET amplification (fluorescence in situ hybridization) in tumor specimens and the relationship to response.

OUTLINE:

Patients receive cabozantinib-s-malate orally (PO) once daily (QD) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

Recruitment & Eligibility

Status
COMPLETED
Sex
Female
Target Recruitment
13
Inclusion Criteria
  • A retrospective review of all patients entered will be performed to confirm clear cell histology; patients must have recurrent or, progressive clear cell ovarian cancer not solely based on cancer antigen (CA)-125; primary tumors must be at least 50% clear cell histomorphology in order to be eligible or have a histologically documented recurrence with at least 50% clear cell histomorphology; recurrence should be biopsy proven unless the tumor is located in an area deemed unsafe to biopsy by the surgeon; if a biopsy can be obtained without significant risk, then biopsy should be obtained

  • If the primary tumor had at least 50% clear cell histomorphology, a biopsy of the recurrent or persistent tumor is not required; the percentage of clear cell histomorphology must be documented in the pathology report or in an addendum to the original report; if slides of the primary tumor are not available for review due to disposal of slides by the histology laboratory (typically 10 years after diagnosis), biopsy of recurrent or persistent disease is required

  • If slides of the primary tumor are not available for review, a biopsy of the recurrent or persistent tumor is required to confirm at least 50% clear cell histomorphology; the percentage of involvement must be documented in the pathology report or in an addendum to the original report

  • All patients must have measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1

  • All patients must submit unstained slides of primary or recurrent tumor for translational analysis

  • Patients must have at least one "target lesion" to be used to assess response on this protocol as defined by RECIST 1.1

  • Patients must have had one prior platinum-based chemotherapeutic regimen for management of primary disease; platinum sensitive and resistant patients are eligible

  • Patients are allowed to receive, but are not required to receive, one additional cytotoxic regimen for management of recurrent or persistent disease

  • Concomitant use of additional anti-neoplastic agents will not be allowed in this study

  • Patients may not have received previous therapy with a MET inhibitor

  • Patients must not be eligible for a higher priority (e.g.; phase II/III), National Surgical Adjuvant Breast and Bowel Project, Radiation Therapy Oncology Group, and Gynecologic Oncology Group (NRG) protocol for the same population if one exists

  • Patients must be recovered from effects of recent surgery (28 days must elapse between surgery and the start of treatment with cabozantinib)

  • Patients must have >= 4 weeks since prior chemotherapy or radiation (>= 6 weeks for nitrosoureas or mitomycin C)

  • Appropriate stage for study entry based on the following diagnostic workup:

    • History/physical examination within 28 days prior to registration
  • The trial is open only to women with recurrent, progressive clear cell carcinoma of the ovary

  • Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2 (Karnofsky >= 60%) within 28 days prior to registration

  • Absolute neutrophil count (ANC) >= 1,500/mcl

  • Platelets greater than or equal to 100,000/mcl

  • Leukocytes >= 3,000/mcL

  • Hemoglobin >= 9 g/dL

  • Serum albumin >= 2.8 g/dL

  • Prothrombin time (PT) such that international normalized ratio (INR) is less than or equal to 1.3 x upper limit of normal (ULN)

  • Partial thromboplastin time (PTT) less than or equal to 1.3 x ULN

  • Creatinine less than or equal to 1.5 times the ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

  • The urine protein: creatinine ratio (UPCR) is derived as follows: protein concentration (mg/dL)/creatinine (mg/dL); patients must have a UPCR < 1.0 to allow participation in the study

  • Bilirubin less than or equal to 1.5 ULN

  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal to 2.5 times the ULN, unless subjects have liver metastasis, in which case both AST and ALT must be less than or equal to 5 times the ULN

  • Lipase less than or equal to 2 x ULN

  • No clinical evidence of pancreatitis

  • Patients must have a normal baseline thyroid stimulating hormone (TSH); a history of hypothyroidism and/or hyperthyroidism is allowed

  • Women of childbearing potential must have a negative pregnancy test at screening; women of childbearing potential include women who have experienced menarche and who have not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or are not postmenopausal; post-menopause is defined as amenorrhea >= 12 consecutive months; note: women who have been amenorrheic for 12 or more months are still considered to be of childbearing potential if the amenorrhea is possibly due to prior chemotherapy, anti-estrogens, ovarian suppression or any other reversible reason; women should stop breastfeeding while participating in this trial; male partners of women participants should also use medically-acceptable forms of contraception during the study

  • The patient must provide study-specific informed consent prior to study entry

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Exclusion Criteria
  • Human immunodeficiency virus (HIV) positive patients

  • Patients with serious non-healing wound, ulcer, or bone fracture

  • Patients with active bleeding or pathologic conditions that carry high risk of bleeding, such as known bleeding disorder, coagulopathy, or tumor involving major vessels

  • The subject requires concomitant treatment, in therapeutic doses, with anticoagulants such as warfarin or warfarin-related agents, heparin, thrombin or factor Xa inhibitors, or antiplatelet agents (e.g., clopidogrel); low dose aspirin (=< 81 mg/day), low-dose warfarin (=< 1 mg/day), and prophylactic low molecular weight heparin (LMWH) are permitted

  • Patients with history or evidence upon physical examination of central nervous system (CNS) disease, including primary brain tumor, seizures not controlled with standard medical therapy, any brain metastases, or history of cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) or subarachnoid hemorrhage within 6 months of the first date of treatment on this study

  • Patients with clinically significant cardiovascular disease; this includes:

    • Poorly controlled hypertension (> 140 mm Hg and > 90 mm Hg for systolic and diastolic blood pressure [BP]) are ineligible
    • Myocardial infarction or unstable angina within 6 months prior to registration; New York Heart Association (NYHA) grade II or greater congestive heart failure
    • Cardiac arrhythmia requiring medication
  • Grade II or greater peripheral vascular disease based on National Cancer Institute (NCI) Common Toxicity Criteria (CTC); e.g. ischemic rest pain, minor tissue loss, and ulceration or gangrene

  • Patients with a pre-existing thyroid abnormality who are unable to maintain thyroid function in the normal range with medication are ineligible; patients with a history of hypothyroidism are eligible provided they are currently euthyroid

  • Patients who have a major surgical procedure, or significant traumatic injury within 28 days prior to the first date of treatment on this study, or anticipation of need for major surgical procedure during the course of the study; patients with placement of vascular access device or core biopsy within 7 days prior to the first date of treatment on this study

  • Patients with other invasive malignancies, with the exception of non-melanoma skin cancer, who had (or have) any evidence of other cancer present within the last 5 years or whose previous cancer treatment contraindicates this protocol therapy

  • Patients must not be eligible for a higher priority NRG clear cell protocol (Gynecologic Oncology Group [GOG]-0283); rare patients ineligible for GOG-0283 may be eligible for this trial without prior treatment on dasatinib therapy (e.g. they have been deemed allergic to dasatinib)

  • Patients who cannot swallow pills

Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Arm && Interventions
GroupInterventionDescription
Treatment (cabozantinib-s-malate)Cabozantinib S-malatePatients receive cabozantinib-s-malate PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Treatment (cabozantinib-s-malate)Laboratory Biomarker AnalysisPatients receive cabozantinib-s-malate PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Primary Outcome Measures
NameTimeMethod
Objective Tumor ResponseEvery 8 weeks during treatment;assessed up to 20 months.

Complete and Partial Tumor Response by RECIST 1.1. Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0) for target lesions and assessed by MRI: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), \>=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR.

The Percentage of Patients Who Survive Progression Free for at Least 6 MonthsEvery 8 weeks during treatment, assessesd up to 6 months for progression free survival.

Progression-free survival (PFS) was defined as the period from study entry until disease progression, death, or the last date of contact. Progression was based on RECIST 1.1. Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1), as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions.

Secondary Outcome Measures
NameTimeMethod
Number of Participants With Grade 3 or Higher Adverse EventsEvery cycle while on treatment, up to 30 days after treatment ends, an average of 14 months.

Grade 3 or higher adverse events were graded by CTC AE v 4.

Progression-free SurvivalTumor scan done every 8 weeks during treatment, Average progression free survival was 3.6 months.

Progression-free survival (PFS) was defined as the period from study entry until disease progression, death, or the last date of contact. Progression was based on RECIST 1.1

Overall SurvivalEvery cycle during treatment, up to 20.1 months.

Overall survival is defined as the duration of time from study entry to time of death or the date of last contact.

Trial Locations

Locations (408)

Sutter Solano Medical Center/Cancer Center

🇺🇸

Vallejo, California, United States

Good Samaritan Regional Health Center

🇺🇸

Mount Vernon, Illinois, United States

Benefis Healthcare- Sletten Cancer Institute

🇺🇸

Great Falls, Montana, United States

Aurora Cancer Care-Waukesha

🇺🇸

Waukesha, Wisconsin, United States

Greenville Health System Cancer Institute-Easley

🇺🇸

Easley, South Carolina, United States

Columbus Oncology and Hematology Associates Inc

🇺🇸

Columbus, Ohio, United States

Riverside Methodist Hospital

🇺🇸

Columbus, Ohio, United States

The Mark H Zangmeister Center

🇺🇸

Columbus, Ohio, United States

Mount Carmel Health Center West

🇺🇸

Columbus, Ohio, United States

UPMC-Saint Margaret

🇺🇸

Pittsburgh, Pennsylvania, United States

UPMC-Shadyside Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

UPMC Jefferson Regional Radiation Oncology

🇺🇸

Pittsburgh, Pennsylvania, United States

UPMC-Passavant Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

UPMC-Saint Clair Hospital Cancer Center

🇺🇸

Pittsburgh, Pennsylvania, United States

Northwestern University

🇺🇸

Chicago, Illinois, United States

Case Western Reserve University

🇺🇸

Cleveland, Ohio, United States

Cleveland Clinic Cancer Center/Fairview Hospital

🇺🇸

Cleveland, Ohio, United States

Cleveland Clinic Foundation

🇺🇸

Cleveland, Ohio, United States

Brigham and Women's Hospital

🇺🇸

Boston, Massachusetts, United States

Dana-Farber Cancer Institute

🇺🇸

Boston, Massachusetts, United States

Minor and James Medical PLLC

🇺🇸

Seattle, Washington, United States

Pacific Gynecology Specialists

🇺🇸

Seattle, Washington, United States

Swedish Medical Center-Ballard Campus

🇺🇸

Seattle, Washington, United States

Indiana University/Melvin and Bren Simon Cancer Center

🇺🇸

Indianapolis, Indiana, United States

Lyndon Baines Johnson General Hospital

🇺🇸

Houston, Texas, United States

M D Anderson Cancer Center

🇺🇸

Houston, Texas, United States

MD Anderson Regional Care Center-Katy

🇺🇸

Houston, Texas, United States

Kaiser Permanente-San Diego Mission

🇺🇸

San Diego, California, United States

Bethesda North Hospital

🇺🇸

Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Blue Ash

🇺🇸

Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Eden Park

🇺🇸

Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Mercy West

🇺🇸

Cincinnati, Ohio, United States

Hawaii Cancer Care Inc-POB II

🇺🇸

Honolulu, Hawaii, United States

Hawaii Oncology Inc-POB I

🇺🇸

Honolulu, Hawaii, United States

Island Urology

🇺🇸

Honolulu, Hawaii, United States

Queen's Medical Center

🇺🇸

Honolulu, Hawaii, United States

Straub Clinic and Hospital

🇺🇸

Honolulu, Hawaii, United States

University of Hawaii Cancer Center

🇺🇸

Honolulu, Hawaii, United States

Hawaii Cancer Care Inc-Liliha

🇺🇸

Honolulu, Hawaii, United States

Hawaii Oncology Inc-Kuakini

🇺🇸

Honolulu, Hawaii, United States

Good Samaritan Hospital - Cincinnati

🇺🇸

Cincinnati, Ohio, United States

Oncology Hematology Care Inc - Anderson

🇺🇸

Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Kenwood

🇺🇸

Cincinnati, Ohio, United States

TriHealth Cancer Institute-Westside

🇺🇸

Cincinnati, Ohio, United States

Jewish Hospital

🇺🇸

Louisville, Kentucky, United States

Abbott-Northwestern Hospital

🇺🇸

Minneapolis, Minnesota, United States

Hennepin County Medical Center

🇺🇸

Minneapolis, Minnesota, United States

Health Partners Inc

🇺🇸

Minneapolis, Minnesota, United States

Billings Clinic-Cody

🇺🇸

Cody, Wyoming, United States

Welch Cancer Center

🇺🇸

Sheridan, Wyoming, United States

Big Horn Basin Cancer Center

🇺🇸

Cody, Wyoming, United States

University of Arizona Cancer Center at Saint Joseph's

🇺🇸

Phoenix, Arizona, United States

Saint Joseph's Hospital and Medical Center

🇺🇸

Phoenix, Arizona, United States

Wayne State University/Karmanos Cancer Institute

🇺🇸

Detroit, Michigan, United States

University of Oklahoma Health Sciences Center

🇺🇸

Oklahoma City, Oklahoma, United States

Providence Portland Medical Center

🇺🇸

Portland, Oregon, United States

Providence Saint Vincent Medical Center

🇺🇸

Portland, Oregon, United States

Alaska Regional Hospital

🇺🇸

Anchorage, Alaska, United States

Alaska Women's Cancer Care

🇺🇸

Anchorage, Alaska, United States

Providence Alaska Medical Center

🇺🇸

Anchorage, Alaska, United States

Sutter Auburn Faith Hospital

🇺🇸

Auburn, California, United States

Kaiser Permanente-Bellflower

🇺🇸

Bellflower, California, United States

Kaiser Permanente Los Angeles Medical Center

🇺🇸

Los Angeles, California, United States

Kaiser Permanente-San Diego Zion

🇺🇸

San Diego, California, United States

Kaiser Permanente-San Marcos

🇺🇸

San Marcos, California, United States

California Pacific Medical Center-Pacific Campus

🇺🇸

San Francisco, California, United States

Palo Alto Medical Foundation-Sunnyvale

🇺🇸

Sunnyvale, California, United States

Northside Hospital-Forsyth

🇺🇸

Cumming, Georgia, United States

Saint Luke's Mountain States Tumor Institute - Fruitland

🇺🇸

Fruitland, Idaho, United States

Wilcox Memorial Hospital and Kauai Medical Clinic

🇺🇸

Lihue, Hawaii, United States

Saint Joseph Medical Center

🇺🇸

Bloomington, Illinois, United States

Saint Luke's Mountain States Tumor Institute

🇺🇸

Boise, Idaho, United States

Kootenai Medical Center

🇺🇸

Coeur d'Alene, Idaho, United States

Saint Luke's Mountain States Tumor Institute - Nampa

🇺🇸

Nampa, Idaho, United States

Cancer Care Specialists of Illinois - Decatur

🇺🇸

Decatur, Illinois, United States

Rush University Medical Center

🇺🇸

Chicago, Illinois, United States

Southern Illinois University School of Medicine

🇺🇸

Springfield, Illinois, United States

Springfield Clinic

🇺🇸

Springfield, Illinois, United States

Rush-Copley Healthcare Center

🇺🇸

Yorkville, Illinois, United States

Franciscan Saint Anthony Health-Michigan City

🇺🇸

Michigan City, Indiana, United States

Woodland Cancer Care Center

🇺🇸

Michigan City, Indiana, United States

Medical Oncology and Hematology Associates-Laurel

🇺🇸

Des Moines, Iowa, United States

Reid Health

🇺🇸

Richmond, Indiana, United States

Cancer Center of Kansas - Parsons

🇺🇸

Parsons, Kansas, United States

Women's Cancer Care Associates LLC

🇺🇸

Albany, New York, United States

Good Samaritan Hospital - Dayton

🇺🇸

Dayton, Ohio, United States

Fairfield Medical Center

🇺🇸

Lancaster, Ohio, United States

Marietta Memorial Hospital

🇺🇸

Marietta, Ohio, United States

Greenville Health System Cancer Institute-Eastside

🇺🇸

Greenville, South Carolina, United States

Providence Newberg Medical Center

🇺🇸

Newberg, Oregon, United States

Greenville Health System Cancer Institute-Spartanburg

🇺🇸

Spartanburg, South Carolina, United States

Harrison HealthPartners Hematology and Oncology-Bremerton

🇺🇸

Bremerton, Washington, United States

Harrison Medical Center

🇺🇸

Bremerton, Washington, United States

MD Anderson Regional Care Center-Sugar Land

🇺🇸

Sugar Land, Texas, United States

Avera Cancer Institute

🇺🇸

Sioux Falls, South Dakota, United States

Greenville Health System Cancer Institute-Seneca

🇺🇸

Seneca, South Carolina, United States

Aurora Health Center-Fond du Lac

🇺🇸

Fond Du Lac, Wisconsin, United States

Sanford Cancer Center Oncology Clinic

🇺🇸

Sioux Falls, South Dakota, United States

Abington Memorial Hospital

🇺🇸

Abington, Pennsylvania, United States

Greenville Health System Cancer Institute-Greer

🇺🇸

Greer, South Carolina, United States

Sanford USD Medical Center - Sioux Falls

🇺🇸

Sioux Falls, South Dakota, United States

Memorial Hospital

🇺🇸

Chattanooga, Tennessee, United States

Cancer Care Center at Island Hospital

🇺🇸

Anacortes, Washington, United States

Monongalia Hospital

🇺🇸

Morgantown, West Virginia, United States

PeaceHealth Saint Joseph Medical Center

🇺🇸

Bellingham, Washington, United States

Aurora Cancer Care-Racine

🇺🇸

Racine, Wisconsin, United States

Providence Saint Mary Regional Cancer Center

🇺🇸

Walla Walla, Washington, United States

Evergreen Hematology and Oncology PS

🇺🇸

Spokane, Washington, United States

Aurora Cancer Care-Grafton

🇺🇸

Grafton, Wisconsin, United States

Aurora Cancer Care-Kenosha South

🇺🇸

Kenosha, Wisconsin, United States

Aurora Bay Area Medical Group-Marinette

🇺🇸

Marinette, Wisconsin, United States

Cancer Center of Western Wisconsin

🇺🇸

New Richmond, Wisconsin, United States

Vince Lombardi Cancer Clinic-Sheboygan

🇺🇸

Sheboygan, Wisconsin, United States

Vince Lombardi Cancer Clinic-Two Rivers

🇺🇸

Two Rivers, Wisconsin, United States

Aurora Cancer Care-Milwaukee West

🇺🇸

Wauwatosa, Wisconsin, United States

Sanford Roger Maris Cancer Center

🇺🇸

Fargo, North Dakota, United States

Cancer Center of Kansas - Wellington

🇺🇸

Wellington, Kansas, United States

Pulmonary Medicine Center of Chattanooga-Hixson

🇺🇸

Hixson, Tennessee, United States

Memorial GYN Plus

🇺🇸

Ooltewah, Tennessee, United States

Southeastern Medical Oncology Center-Jacksonville

🇺🇸

Jacksonville, North Carolina, United States

Southeastern Medical Oncology Center-Wilson

🇺🇸

Wilson, North Carolina, United States

Kaiser Permanente-Woodland Hills

🇺🇸

Woodland Hills, California, United States

Saint Clare Hospital

🇺🇸

Lakewood, Washington, United States

Rockwood Clinic Cancer Treatment Center-Valley

🇺🇸

Spokane Valley, Washington, United States

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

🇺🇸

Yakima, Washington, United States

Providence Regional Cancer System-Yelm

🇺🇸

Yelm, Washington, United States

Aurora Medical Center in Summit

🇺🇸

Summit, Wisconsin, United States

CoxHealth South Hospital

🇺🇸

Springfield, Missouri, United States

PeaceHealth Saint John Medical Center

🇺🇸

Longview, Washington, United States

Alaska Oncology and Hematology LLC

🇺🇸

Anchorage, Alaska, United States

Alaska Breast Care and Surgery LLC

🇺🇸

Anchorage, Alaska, United States

Anchorage Radiation Therapy Center

🇺🇸

Anchorage, Alaska, United States

Anchorage Oncology Centre

🇺🇸

Anchorage, Alaska, United States

Katmai Oncology Group

🇺🇸

Anchorage, Alaska, United States

CHI Saint Vincent Cancer Center Hot Springs

🇺🇸

Hot Springs, Arkansas, United States

Sutter Cancer Centers Radiation Oncology Services-Auburn

🇺🇸

Auburn, California, United States

Kaiser Permanente-Anaheim

🇺🇸

Anaheim, California, United States

Alta Bates Summit Medical Center-Herrick Campus

🇺🇸

Berkeley, California, United States

Mills-Peninsula Medical Center

🇺🇸

Burlingame, California, United States

Providence Saint Joseph Medical Center/Disney Family Cancer Center

🇺🇸

Burbank, California, United States

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

🇺🇸

Cameron Park, California, United States

Kaiser Permanente-Baldwin Park

🇺🇸

Baldwin Park, California, United States

Sutter Davis Hospital

🇺🇸

Davis, California, United States

Eden Hospital Medical Center

🇺🇸

Castro Valley, California, United States

Kaiser Permanente - Harbor City

🇺🇸

Harbor City, California, United States

Kaiser Permanente-Fontana

🇺🇸

Fontana, California, United States

Kaiser Permanente-Irvine

🇺🇸

Irvine, California, United States

Sutter Cancer Research Consortium

🇺🇸

Novato, California, United States

Palo Alto Medical Foundation-Camino Division

🇺🇸

Mountain View, California, United States

Kaiser Permanente-Cadillac

🇺🇸

Los Angeles, California, United States

Memorial Medical Center

🇺🇸

Springfield, Illinois, United States

Palo Alto Medical Foundation Health Care

🇺🇸

Palo Alto, California, United States

Palo Alto Medical Foundation-Gynecologic Oncology

🇺🇸

Mountain View, California, United States

Kaiser Permanente-Riverside

🇺🇸

Riverside, California, United States

Sutter Roseville Medical Center

🇺🇸

Roseville, California, United States

Sutter Cancer Centers Radiation Oncology Services-Roseville

🇺🇸

Roseville, California, United States

Kaiser Permanente - Panorama City

🇺🇸

Panorama City, California, United States

Palo Alto Medical Foundation-Santa Cruz

🇺🇸

Santa Cruz, California, United States

Sutter Pacific Medical Foundation

🇺🇸

Santa Rosa, California, United States

Sutter Cancer Centers Radiation Oncology Services-Vacaville

🇺🇸

Vacaville, California, United States

Northside Hospital

🇺🇸

Atlanta, Georgia, United States

Hawaii Oncology Inc-Pali Momi

🇺🇸

'Aiea, Hawaii, United States

Northeast Georgia Medical Center-Gainesville

🇺🇸

Gainesville, Georgia, United States

Pali Momi Medical Center

🇺🇸

'Aiea, Hawaii, United States

The Cancer Center of Hawaii-Pali Momi

🇺🇸

'Aiea, Hawaii, United States

Saint Luke's Mountain States Tumor Institute - Meridian

🇺🇸

Meridian, Idaho, United States

Kootenai Cancer Center

🇺🇸

Post Falls, Idaho, United States

Kootenai Cancer Clinic

🇺🇸

Sandpoint, Idaho, United States

Saint Luke's Mountain States Tumor Institute-Twin Falls

🇺🇸

Twin Falls, Idaho, United States

Illinois CancerCare-Canton

🇺🇸

Canton, Illinois, United States

Illinois CancerCare-Bloomington

🇺🇸

Bloomington, Illinois, United States

Rush - Copley Medical Center

🇺🇸

Aurora, Illinois, United States

Memorial Hospital of Carbondale

🇺🇸

Carbondale, Illinois, United States

Carle on Vermilion

🇺🇸

Danville, Illinois, United States

Illinois CancerCare-Carthage

🇺🇸

Carthage, Illinois, United States

Centralia Oncology Clinic

🇺🇸

Centralia, Illinois, United States

Carle Physician Group-Effingham

🇺🇸

Effingham, Illinois, United States

Decatur Memorial Hospital

🇺🇸

Decatur, Illinois, United States

Illinois CancerCare-Galesburg

🇺🇸

Galesburg, Illinois, United States

Crossroads Cancer Center

🇺🇸

Effingham, Illinois, United States

Illinois CancerCare-Eureka

🇺🇸

Eureka, Illinois, United States

Western Illinois Cancer Treatment Center

🇺🇸

Galesburg, Illinois, United States

Illinois CancerCare-Macomb

🇺🇸

Macomb, Illinois, United States

Sudarshan K Sharma MD Limited-Gynecologic Oncology

🇺🇸

Hinsdale, Illinois, United States

Illinois CancerCare-Kewanee Clinic

🇺🇸

Kewanee, Illinois, United States

Illinois CancerCare-Ottawa Clinic

🇺🇸

Ottawa, Illinois, United States

Carle Physician Group-Mattoon/Charleston

🇺🇸

Mattoon, Illinois, United States

Radiation Oncology of Northern Illinois

🇺🇸

Ottawa, Illinois, United States

Illinois CancerCare-Pekin

🇺🇸

Pekin, Illinois, United States

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center

🇺🇸

Pekin, Illinois, United States

Illinois CancerCare-Peoria

🇺🇸

Peoria, Illinois, United States

Methodist Medical Center of Illinois

🇺🇸

Peoria, Illinois, United States

OSF Saint Francis Radiation Oncology at Peoria Cancer Center

🇺🇸

Peoria, Illinois, United States

Valley Radiation Oncology

🇺🇸

Peru, Illinois, United States

Illinois CancerCare-Peru

🇺🇸

Peru, Illinois, United States

Central Illinois Hematology Oncology Center

🇺🇸

Springfield, Illinois, United States

Illinois CancerCare-Princeton

🇺🇸

Princeton, Illinois, United States

Carle Cancer Center

🇺🇸

Urbana, Illinois, United States

The Carle Foundation Hospital

🇺🇸

Urbana, Illinois, United States

Cancer Care Specialists of Illinois-Swansea

🇺🇸

Swansea, Illinois, United States

Northwestern Medicine Cancer Center Warrenville

🇺🇸

Warrenville, Illinois, United States

OSF Saint Francis Medical Center

🇺🇸

Peoria, Illinois, United States

Saint Vincent Hospital and Health Care Center

🇺🇸

Indianapolis, Indiana, United States

Mary Greeley Medical Center

🇺🇸

Ames, Iowa, United States

McFarland Clinic PC - Ames

🇺🇸

Ames, Iowa, United States

McFarland Clinic PC-Boone

🇺🇸

Boone, Iowa, United States

Medical Oncology and Hematology Associates-West Des Moines

🇺🇸

Clive, Iowa, United States

Greater Regional Medical Center

🇺🇸

Creston, Iowa, United States

Alegent Health Mercy Hospital

🇺🇸

Council Bluffs, Iowa, United States

Mercy Cancer Center-West Lakes

🇺🇸

Clive, Iowa, United States

Mercy Medical Center - Des Moines

🇺🇸

Des Moines, Iowa, United States

McFarland Clinic PC-Trinity Cancer Center

🇺🇸

Fort Dodge, Iowa, United States

University of Iowa/Holden Comprehensive Cancer Center

🇺🇸

Iowa City, Iowa, United States

McFarland Clinic PC-Jefferson

🇺🇸

Jefferson, Iowa, United States

McFarland Clinic PC-Marshalltown

🇺🇸

Marshalltown, Iowa, United States

Cancer Center of Kansas - Chanute

🇺🇸

Chanute, Kansas, United States

Cancer Center of Kansas - Dodge City

🇺🇸

Dodge City, Kansas, United States

Mercy Medical Center-West Lakes

🇺🇸

West Des Moines, Iowa, United States

Cancer Center of Kansas - El Dorado

🇺🇸

El Dorado, Kansas, United States

Cancer Center of Kansas-Kingman

🇺🇸

Kingman, Kansas, United States

Lawrence Memorial Hospital

🇺🇸

Lawrence, Kansas, United States

Cancer Center of Kansas-Independence

🇺🇸

Independence, Kansas, United States

Cancer Center of Kansas-Liberal

🇺🇸

Liberal, Kansas, United States

Cancer Center of Kansas - Newton

🇺🇸

Newton, Kansas, United States

Cancer Center of Kansas - Pratt

🇺🇸

Pratt, Kansas, United States

Cancer Center of Kansas - Salina

🇺🇸

Salina, Kansas, United States

Associates In Womens Health

🇺🇸

Wichita, Kansas, United States

Cancer Center of Kansas - Wichita

🇺🇸

Wichita, Kansas, United States

Cancer Center of Kansas-Wichita Medical Arts Tower

🇺🇸

Wichita, Kansas, United States

Cancer Center of Kansas - Winfield

🇺🇸

Winfield, Kansas, United States

Via Christi Regional Medical Center

🇺🇸

Wichita, Kansas, United States

Flaget Memorial Hospital

🇺🇸

Bardstown, Kentucky, United States

Saint Joseph Radiation Oncology Resource Center

🇺🇸

Lexington, Kentucky, United States

Saint Joseph Hospital East

🇺🇸

Lexington, Kentucky, United States

Commonwealth Cancer Center-Corbin

🇺🇸

Corbin, Kentucky, United States

Oncology Hematology Care Inc-Crestview

🇺🇸

Crestview Hills, Kentucky, United States

Woman's Hospital

🇺🇸

Baton Rouge, Louisiana, United States

Jewish Hospital Medical Center South

🇺🇸

Shepherdsville, Kentucky, United States

Maine Medical Center- Scarborough Campus

🇺🇸

Scarborough, Maine, United States

Johns Hopkins University/Sidney Kimmel Cancer Center

🇺🇸

Baltimore, Maryland, United States

Bronson Battle Creek

🇺🇸

Battle Creek, Michigan, United States

Weisberg Cancer Treatment Center

🇺🇸

Farmington Hills, Michigan, United States

Mercy Health Saint Mary's

🇺🇸

Grand Rapids, Michigan, United States

Spectrum Health at Butterworth Campus

🇺🇸

Grand Rapids, Michigan, United States

Borgess Medical Center

🇺🇸

Kalamazoo, Michigan, United States

Bronson Methodist Hospital

🇺🇸

Kalamazoo, Michigan, United States

Mercy Health Mercy Campus

🇺🇸

Muskegon, Michigan, United States

West Michigan Cancer Center

🇺🇸

Kalamazoo, Michigan, United States

Lakeland Hospital Niles

🇺🇸

Niles, Michigan, United States

Spectrum Health Reed City Hospital

🇺🇸

Reed City, Michigan, United States

Lakeland Medical Center Saint Joseph

🇺🇸

Saint Joseph, Michigan, United States

Munson Medical Center

🇺🇸

Traverse City, Michigan, United States

Marie Yeager Cancer Center

🇺🇸

Saint Joseph, Michigan, United States

Sanford Joe Lueken Cancer Center

🇺🇸

Bemidji, Minnesota, United States

Fairview Ridges Hospital

🇺🇸

Burnsville, Minnesota, United States

Mercy Hospital

🇺🇸

Coon Rapids, Minnesota, United States

Unity Hospital

🇺🇸

Fridley, Minnesota, United States

Fairview-Southdale Hospital

🇺🇸

Edina, Minnesota, United States

Saint John's Hospital - Healtheast

🇺🇸

Maplewood, Minnesota, United States

Minnesota Oncology Hematology PA-Maplewood

🇺🇸

Maplewood, Minnesota, United States

New Ulm Medical Center

🇺🇸

New Ulm, Minnesota, United States

North Memorial Medical Health Center

🇺🇸

Robbinsdale, Minnesota, United States

Park Nicollet Clinic - Saint Louis Park

🇺🇸

Saint Louis Park, Minnesota, United States

United Hospital

🇺🇸

Saint Paul, Minnesota, United States

Saint Francis Regional Medical Center

🇺🇸

Shakopee, Minnesota, United States

Regions Hospital

🇺🇸

Saint Paul, Minnesota, United States

Lakeview Hospital

🇺🇸

Stillwater, Minnesota, United States

Rice Memorial Hospital

🇺🇸

Willmar, Minnesota, United States

Ridgeview Medical Center

🇺🇸

Waconia, Minnesota, United States

Minnesota Oncology Hematology PA-Woodbury

🇺🇸

Woodbury, Minnesota, United States

Parkland Health Center-Bonne Terre

🇺🇸

Bonne Terre, Missouri, United States

Central Care Cancer Center - Bolivar

🇺🇸

Bolivar, Missouri, United States

Saint Francis Medical Center

🇺🇸

Cape Girardeau, Missouri, United States

Cox Cancer Center Branson

🇺🇸

Branson, Missouri, United States

Freeman Health System

🇺🇸

Joplin, Missouri, United States

Mercy Hospital Joplin

🇺🇸

Joplin, Missouri, United States

Capital Region Southwest Campus

🇺🇸

Jefferson City, Missouri, United States

Saint Louis Cancer and Breast Institute-South City

🇺🇸

Saint Louis, Missouri, United States

Mercy Hospital Saint Louis

🇺🇸

Saint Louis, Missouri, United States

Mercy Clinic-Rolla-Cancer and Hematology

🇺🇸

Rolla, Missouri, United States

Missouri Baptist Medical Center

🇺🇸

Saint Louis, Missouri, United States

Sainte Genevieve County Memorial Hospital

🇺🇸

Sainte Genevieve, Missouri, United States

Mercy Hospital Springfield

🇺🇸

Springfield, Missouri, United States

Missouri Baptist Outpatient Center-Sunset Hills

🇺🇸

Sunset Hills, Missouri, United States

Missouri Baptist Sullivan Hospital

🇺🇸

Sullivan, Missouri, United States

Delbert Day Cancer Institute at PCRMC

🇺🇸

Rolla, Missouri, United States

Southeast Cancer Center

🇺🇸

Cape Girardeau, Missouri, United States

Billings Clinic Cancer Center

🇺🇸

Billings, Montana, United States

Saint Vincent Healthcare

🇺🇸

Billings, Montana, United States

Bozeman Deaconess Hospital

🇺🇸

Bozeman, Montana, United States

Saint James Community Hospital and Cancer Treatment Center

🇺🇸

Butte, Montana, United States

Saint Peter's Community Hospital

🇺🇸

Helena, Montana, United States

Kalispell Regional Medical Center

🇺🇸

Kalispell, Montana, United States

Saint Patrick Hospital - Community Hospital

🇺🇸

Missoula, Montana, United States

CHI Health Good Samaritan

🇺🇸

Kearney, Nebraska, United States

CHI Health Saint Francis

🇺🇸

Grand Island, Nebraska, United States

Heartland Hematology and Oncology

🇺🇸

Kearney, Nebraska, United States

Saint Elizabeth Regional Medical Center

🇺🇸

Lincoln, Nebraska, United States

Midlands Community Hospital

🇺🇸

Papillion, Nebraska, United States

Women's Cancer Center of Nevada

🇺🇸

Las Vegas, Nevada, United States

University of New Mexico Cancer Center

🇺🇸

Albuquerque, New Mexico, United States

Southwest Gynecologic Oncology Associates Inc

🇺🇸

Albuquerque, New Mexico, United States

Sampson Radiation Oncology

🇺🇸

Clinton, North Carolina, United States

Southeastern Medical Oncology Center-Goldsboro

🇺🇸

Goldsboro, North Carolina, United States

Southeastern Medical Oncology Center-Clinton

🇺🇸

Clinton, North Carolina, United States

Wayne Radiation Oncology

🇺🇸

Goldsboro, North Carolina, United States

Wayne Memorial Hospital

🇺🇸

Goldsboro, North Carolina, United States

Sanford Broadway Medical Center

🇺🇸

Fargo, North Dakota, United States

Sanford Bismarck Medical Center

🇺🇸

Bismarck, North Dakota, United States

Onslow Memorial Hospital

🇺🇸

Jacksonville, North Carolina, United States

Sanford Clinic North-Fargo

🇺🇸

Fargo, North Dakota, United States

UHHS-Chagrin Highlands Medical Center

🇺🇸

Beachwood, Ohio, United States

Miami Valley Hospital South

🇺🇸

Centerville, Ohio, United States

Adena Regional Medical Center

🇺🇸

Chillicothe, Ohio, United States

Strecker Cancer Center-Belpre

🇺🇸

Belpre, Ohio, United States

TriHealth Cancer Institute-Anderson

🇺🇸

Cincinnati, Ohio, United States

Grant Medical Center

🇺🇸

Columbus, Ohio, United States

Miami Valley Hospital

🇺🇸

Dayton, Ohio, United States

Doctors Hospital

🇺🇸

Columbus, Ohio, United States

Oncology Hematology Care Inc-Healthplex

🇺🇸

Fairfield, Ohio, United States

Miami Valley Hospital North

🇺🇸

Dayton, Ohio, United States

Grady Memorial Hospital

🇺🇸

Delaware, Ohio, United States

Delaware Health Center-Grady Cancer Center

🇺🇸

Delaware, Ohio, United States

Delaware Radiation Oncology

🇺🇸

Delaware, Ohio, United States

Atrium Medical Center-Middletown Regional Hospital

🇺🇸

Franklin, Ohio, United States

Wayne Hospital

🇺🇸

Greenville, Ohio, United States

Blanchard Valley Hospital

🇺🇸

Findlay, Ohio, United States

Kettering Medical Center

🇺🇸

Kettering, Ohio, United States

Hillcrest Hospital Cancer Center

🇺🇸

Mayfield Heights, Ohio, United States

UH Seidman Cancer Center at Landerbrook Health Center

🇺🇸

Mayfield Heights, Ohio, United States

UH Seidman Cancer Center at Lake Health Mentor Campus

🇺🇸

Mentor, Ohio, United States

Licking Memorial Hospital

🇺🇸

Newark, Ohio, United States

Knox Community Hospital

🇺🇸

Mount Vernon, Ohio, United States

Southern Ohio Medical Center

🇺🇸

Portsmouth, Ohio, United States

Newark Radiation Oncology

🇺🇸

Newark, Ohio, United States

Springfield Regional Cancer Center

🇺🇸

Springfield, Ohio, United States

Upper Valley Medical Center

🇺🇸

Troy, Ohio, United States

University Hospitals Sharon Health Center

🇺🇸

Wadsworth, Ohio, United States

Oklahoma Cancer Specialists and Research Institute-Tulsa

🇺🇸

Tulsa, Oklahoma, United States

Saint Ann's Hospital

🇺🇸

Westerville, Ohio, United States

Springfield Regional Medical Center

🇺🇸

Springfield, Ohio, United States

Genesis Healthcare System Cancer Care Center

🇺🇸

Zanesville, Ohio, United States

UHHS-Westlake Medical Center

🇺🇸

Westlake, Ohio, United States

Providence Oncology and Hematology Care Southeast

🇺🇸

Clackamas, Oregon, United States

Clackamas Radiation Oncology Center

🇺🇸

Clackamas, Oregon, United States

Saint Charles Health System

🇺🇸

Bend, Oregon, United States

Bay Area Hospital

🇺🇸

Coos Bay, Oregon, United States

Providence Willamette Falls Medical Center

🇺🇸

Oregon City, Oregon, United States

UPMC Cancer Centers - Arnold Palmer Pavilion

🇺🇸

Greensburg, Pennsylvania, United States

UPMC-Johnstown/John P. Murtha Regional Cancer Center

🇺🇸

Johnstown, Pennsylvania, United States

UPMC Cancer Center at UPMC McKeesport

🇺🇸

McKeesport, Pennsylvania, United States

UPMC-Heritage Valley Health System Beaver

🇺🇸

Beaver, Pennsylvania, United States

University of Pennsylvania/Abramson Cancer Center

🇺🇸

Philadelphia, Pennsylvania, United States

UPMC-Presbyterian Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

UPMC-Coraopolis/Heritage Valley Radiation Oncology

🇺🇸

Moon, Pennsylvania, United States

UPMC-Magee Womens Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

University of Pittsburgh Cancer Institute (UPCI)

🇺🇸

Pittsburgh, Pennsylvania, United States

UPMC Cancer Center at UPMC Northwest

🇺🇸

Seneca, Pennsylvania, United States

UPMC Uniontown Hospital Radiation Oncology

🇺🇸

Uniontown, Pennsylvania, United States

Saint Francis Hospital

🇺🇸

Federal Way, Washington, United States

UPMC Washington Hospital Radiation Oncology

🇺🇸

Washington, Pennsylvania, United States

Greenville Health System Cancer Institute-Faris

🇺🇸

Greenville, South Carolina, United States

Greenville Health System Cancer Institute-Andrews

🇺🇸

Greenville, South Carolina, United States

Greenville Health System Cancer Institute-Butternut

🇺🇸

Greenville, South Carolina, United States

Saint Francis Cancer Center

🇺🇸

Greenville, South Carolina, United States

MD Anderson Regional Care Center-Bay Area

🇺🇸

Nassau Bay, Texas, United States

MD Anderson Regional Care Center-The Woodlands

🇺🇸

The Woodlands, Texas, United States

Providence Regional Cancer System-Aberdeen

🇺🇸

Aberdeen, Washington, United States

Swedish Cancer Institute-Eastside Oncology Hematology

🇺🇸

Bellevue, Washington, United States

Highline Medical Center-Main Campus

🇺🇸

Burien, Washington, United States

Swedish Cancer Institute-Edmonds

🇺🇸

Edmonds, Washington, United States

Providence Regional Cancer System-Centralia

🇺🇸

Centralia, Washington, United States

Providence Regional Cancer Partnership

🇺🇸

Everett, Washington, United States

Saint Elizabeth Hospital

🇺🇸

Enumclaw, Washington, United States

Swedish Cancer Institute-Issaquah

🇺🇸

Issaquah, Washington, United States

Providence Regional Cancer System-Lacey

🇺🇸

Lacey, Washington, United States

Harrison HealthPartners Hematology and Oncology-Poulsbo

🇺🇸

Poulsbo, Washington, United States

Kaiser Permanente Washington

🇺🇸

Seattle, Washington, United States

Swedish Medical Center-First Hill

🇺🇸

Seattle, Washington, United States

Providence Regional Cancer System-Shelton

🇺🇸

Shelton, Washington, United States

Franciscan Research Center-Northwest Medical Plaza

🇺🇸

Tacoma, Washington, United States

PeaceHealth Southwest Medical Center

🇺🇸

Vancouver, Washington, United States

Rockwood Cancer Treatment Center-DHEC-Downtown

🇺🇸

Spokane, Washington, United States

Northwest Medical Specialties PLLC

🇺🇸

Tacoma, Washington, United States

Aurora Cancer Care-Southern Lakes VLCC

🇺🇸

Burlington, Wisconsin, United States

Aurora Health Care Germantown Health Center

🇺🇸

Germantown, Wisconsin, United States

Aurora BayCare Medical Center

🇺🇸

Green Bay, Wisconsin, United States

Vince Lombardi Cancer Clinic - Oshkosh

🇺🇸

Oshkosh, Wisconsin, United States

Aurora West Allis Medical Center

🇺🇸

West Allis, Wisconsin, United States

Sutter Medical Center Sacramento

🇺🇸

Sacramento, California, United States

Nebraska Methodist Hospital

🇺🇸

Omaha, Nebraska, United States

Alegent Health Immanuel Medical Center

🇺🇸

Omaha, Nebraska, United States

Hematology and Oncology Consultants PC

🇺🇸

Omaha, Nebraska, United States

Creighton University Medical Center

🇺🇸

Omaha, Nebraska, United States

Alegent Health Bergan Mercy Medical Center

🇺🇸

Omaha, Nebraska, United States

Alegent Health Lakeside Hospital

🇺🇸

Omaha, Nebraska, United States

Aurora Cancer Care-Milwaukee

🇺🇸

Milwaukee, Wisconsin, United States

Aurora Saint Luke's Medical Center

🇺🇸

Milwaukee, Wisconsin, United States

Froedtert and the Medical College of Wisconsin

🇺🇸

Milwaukee, Wisconsin, United States

Aurora Sinai Medical Center

🇺🇸

Milwaukee, Wisconsin, United States

Community Medical Hospital

🇺🇸

Missoula, Montana, United States

University of Florida Health Science Center - Gainesville

🇺🇸

Gainesville, Florida, United States

The Cancer Center of Hawaii-Liliha

🇺🇸

Honolulu, Hawaii, United States

Kapiolani Medical Center for Women and Children

🇺🇸

Honolulu, Hawaii, United States

Kuakini Medical Center

🇺🇸

Honolulu, Hawaii, United States

Saints Mary and Elizabeth Hospital

🇺🇸

Louisville, Kentucky, United States

Jewish Hospital Medical Center Northeast

🇺🇸

Louisville, Kentucky, United States

Cancer Center of Kansas - Fort Scott

🇺🇸

Fort Scott, Kansas, United States

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