卡波替尼 (Cabometyx, Cometriq)

概览

Cabozantinib is a tyrosine kinase inhibitor used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer.

作用机制

Cabozantinib inhibits specific receptor tyrosine kinases such as VEGFR-1, -2 and -3, KIT, TRKB, FLT-3, AXL, RET, MET, and TIE-2.

适应症

⑴治疗进展的、不能切除的局部晚期或转移的髓性甲状腺癌。 ⑵用于舒尼替尼（索坦）治疗失败的晚期肾癌。

• Advanced Renal Cell Carcinoma
• Hepatocellular Carcinoma
• Metastatic Differentiated Thyroid Cancer
• Locally advanced Differentiated Thyroid Cancer (DTC)
• Metastatic Clear Cell Renal Cell Carcinoma (ccRCC)
• Progressive, metastatic Medullary thyroid cancer