Primary Percutaneous Intracoronary Thrombolysis - Tenecteplase : A pilot study - P-PIT Trial

DR C N MANJUNATH0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•(a) Men aged 40 years old or younger
•(b) Women aged 40 years old or younger
•(c) Presentation to hospital < 6 hours after the index pain.
•(d) All patients with diagnosis of STEMI, as evidenced by:
•Detection of a rise and/or fall in cardiac biomarker value (Trop-T), with at least one value above the 99th percentile of the upper reference range and with at least one of the following:
•-Symptoms of ischemia
•-New or presumed new significant ST-segment T wave (ST-T) changes or new LBBB
•-Development of pathologic Q waves on the ECG
•-Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality
•-Identification of an intracoronary thrombus by angiography

•(a)Patients with previous history of ischemic heart disease/ PTCA / CABG.
•(b)Patients with history of cardiomyopathy
•(c)Patients with mechanical complications of STEMI
•(d)Resuscitated Cardiac Arrest, severe LV dysfunction, Kilip-III and IV on presentation to hospital.
•(e)Patients with unstable haemodynamics
•(f)Patients with absolute contraindications for the use of fibrinolytic agents:
•-Any previous intracranial haemorrhage
•-Known structural cerebral vascular lesion (e.g., arteriovenous malformation)
•-Known malignant intracranial neoplasm (primary or metastatic)
•-Ischemic stroke within 3 months except acute ischemic stroke within 4.5 hours
•-Suspected aortic dissection
•-Active bleeding or bleeding diathesis (excluding menses)
•-Significant closed-head or facial trauma within 3 months
•-Intracranial or intraspinal surgery within 2 months
•-Severe uncontrolled hypertension (unresponsive to emergency therapy)
•(g)Patients having a history of diabetes mellitus, chronic alcoholism, concomitant liver, kidney disease, cerebrovascular disease and acute / chronic infection
•(e) Patients unwilling to give informed consent

发起方

DR C N MANJUNATH