Serum Uromodulin and DN Systematic Review and Meta Analysis

Completed

• Conditions: Diabetic Nephropathies
• Interventions: Diagnostic Test: The association of serum uromodulin with DN; Diagnostic Test: The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

• Registration Number: NCT06596863
• Lead Sponsor: Tanta University

Brief Summary

Several studies have investigated the association between the changes of serum uromodulin and diabetic nephropathy (DN). However, the results are still controversial. Hence, this meta-analysis aimed to evaluate the association of uromodulin with DN.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-05-01
• Primary Completion: 2024-05-30
• Study Completion: 2024-05-30
• Status Verified: 2024-09
• Study First Submitted: 2024-09-11
• Study First Submitted QC: 2024-09-14
• Last Update Submitted: 2024-09-14
• Study First Posted: 2024-09-19
• Last Update Posted: 2024-09-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1774

Inclusion Criteria

• Studies were included if they met the following criteria:

  1. serum level of uromodulin was determined;
  2. the samples were enrolled from diabetic patients;
  3. mean ± SD was reported for uromodulin between patients with and without DN;
  4. the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN was determined

Exclusion Criteria

• Studies were excluded according to the following criteria:

  1. duplicate studies;
  2. review articles;
  3. non original research articles;
  4. studies with insufficient data to extract;
  5. non-human research;
  6. studies that determined urine level of uromodulin.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control group	The association of serum uromodulin with DN	Included 862 healthy subjects as control group
Control group	The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN	Included 862 healthy subjects as control group
DKD group	The association of serum uromodulin with DN	Included 912 patients with DN
DKD group	The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN	Included 912 patients with DN

Primary Outcome Measures

Name	Time	Method
Association of serum uromodulin with DKD: asystematic review and meta analysis	may, 2024	Evaluate the meta analysis of association of serum uromodulin in the 3 diabetic group comparing with each other and compare them to the control group and correlate these results with other kidney biomarker

Trial Locations

Locations (1)

Tanta Yniversity; 🇪🇬 Tanta, Yes, Egypt