Amino Acids Versus Magnesium Sulphate Infusion in Controlling Postoperative Shivering
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Postoperative shivering grade
研究概览
简要总结
Aim of the study is comparing the effect of amino acid versus magnesium sulfate infusion on postoperative shivering in patients undergoing elective percutaneous nephrolithotomy surgery under general anesthesia.
详细描述
A written informed consent was taken from the patients. Patients were assigned randomly to two groups (40 subjects each) to be anesthetized and infused with either an iv amino acid starting just before and during anesthesia (group A) or an iv magnesium sulphate starting just before and during anesthesia (group M) in the perioperative period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I-II who were listed for elective percutaneous nephrolithotomy PCNL surgery under general anesthesia.
排除标准
- •Hepatic inefficiency
- •Renal inefficiency
- •Spinal anesthesia because of a different mechanism of hypothermia
研究组 & 干预措施
aminoacid group
patients received an IV amino acid infusion 150 ml/kg/hr starting just before and during anesthesia
干预措施: Aminoacid (Drug)
magnesium sulfate group
patients received an IV magnesium sulphate bolus and infusion 40 mg/kg starting just before and during anesthesia
干预措施: Magnesium sulfate (Drug)
结局指标
主要结局
Postoperative shivering grade
时间窗: 2 hours postoperative
"grading of shivering," in which shivering degree was assessed as 1 of 5 levels (0, 1, 2, 3, and 4), grade 0 lack of shivering, grade 1 slight shivering (inconsiderable yet apparent peripheral vasoconstriction), grade 2 medium level shivering (muscular activity in one muscle group only) grade 3 severe shivering (muscular activity in more than one muscle group without generalized shivering) and grade 4 generalized shivering.
次要结局
- Shivering frequency(2 hours postoperative)
- Blood loss volume(2 hours postoperative)
研究者
Omar Makram Soliman
lecturer of anesthesia
Assiut University