Study on the mechanism of Hewei Jiangni recipe on NERD based on the correlation analysis of intestinal flora and metabolites
- Conditions
- on-erosive reflux disease
- Registration Number
- ITMCTR2100004519
- Lead Sponsor
- Dongfang Hospital of Beijing University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1. Nerd outpatients meet the diagnostic criteria of Western medicine nerd, and at the same time meet the diagnostic criteria of TCM cold and heat syndrome;
2. Patients aged 18-65 years;
3. Patients who voluntarily participated in this study and signed informed consent.
1. Patients diagnosed with reflux esophagitis, high sensitivity of reflux and Barrett's esophagus;
2. Patients with history of upper gastrointestinal bleeding or surgery, esophageal stenosis, esophageal and gastric tumor and other organic diseases;
3. Patients with serious primary diseases such as cardiovascular, cerebrovascular, liver, kidney and hematopoietic system;
4. Patients who have taken other drugs or therapies (proton pump inhibitors, H2 receptor antagonists, gastric mucosal protectors) related to the curative effect of the disease within 2 weeks;
5. Women who are breast-feeding, pregnant or preparing for pregnancy;
6. Patients with anxiety or depression;
7. Patients with mental or nervous system history or mental or language disorders;
8. Allergic constitution and patients allergic to known components of the drug in this study;
9. Subjects who participated in other clinical trials within three months.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method GERD-Q scale score;
- Secondary Outcome Measures
Name Time Method SF-36 quality of Life scale;PRO self-rating scale score;Syndrome score of traditional Chinese medicine;