Research on a new mechanism of Huang-lian-Jie-du Decoction's inhibition of gingipains to regulate

Suining Central Hospital0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

暂无简介。

•1. The subject signs the informed consent form and is willing to be tested. The process of obtaining informed consent should comply with Good Clinical Practice regulations.
•2. Aged 18–65 years, meets the diagnostic criteria of Western medicine for mild to moderate chronic periodontitis and meets the TCM criteria for syndrome differentiation of stomach fire flaring gum.
•3. At least 20 teeth in the whole mouth that can be evaluated for periodontal assessment.
•4. No history of smoking.
•5. Medical history and results of physical examination within 1 year will be requested. There is no history of systemic disease, immune-related disease or orthodontic treatment.
•6. No use of immunosuppressive drugs within 3 months.
•7. Women are not pregnant or breastfeeding.
•8. No periodontal treatment within 6 months.
•9. No use of antibiotics or non-steroidal anti-inflammatory drugs within 2 weeks.
•10. No long-term use of drugs that cause gingival hyperplasia or interfere with the recovery of periodontal tissue.

•1. Is under 18 years old or over 65 years old.
•2. Has severe heart, liver, lung or kidney damage.
•3. Is infected in other areas or suffering from an immune disease.
•4. Is a lactating or pregnant woman.
•5. Is undergoing orthodontic treatment or wearing removable partial dentures.
•6. Suffers from complications such as gingival hyperplasia, periodontal abscess, retrograde pulpitis, secondary occlusal trauma or concomitant oral mucosal disease.
•7. Is currently participating in another clinical trial or receiving another related treatment that can affect the observed indicators.
•8. Is completely unwilling to communicate and cooperate, mentally abnormal or unwilling to sign the informed consent form.

发起方

Suining Central Hospital