Detection of Mast cells in Systemic Mastocytosis

• Conditions: Mast cell disorder; 10018865

• Registration Number: NL-OMON44206
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Older than 18 years
Diagnosed with systemic mastocytosis according to WHO criteria
Informed written consent

Exclusion Criteria

Younger than 18 years
No informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To study the reliable identification of mast cells in peripheral blood of<br /><br>patients with systemic mastocytosis and investigate if numbers and/or phenotype<br /><br>(expression of aberrant markers) differ from healthy controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To study numbers and phenotype of other leukocyte subsets (with an emphasis on<br /><br>IgE+ B cells) in peripheral blood of patients with SM compared to healthy<br /><br>controls.</p><br>