Effect of Exercise Training in Patients With Heart Failure and Permanent Atrial Fibrillation
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- University of Sao Paulo General Hospital
- Enrollment
- 13
- Locations
- 1
- Primary Endpoint
- Functional Capacity Assessement
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The positive effect of physical training in patients with heart failure (HF) has been increasingly established. However, the presence of atrial fibrillation (AF), mainly in its permanent form, makes the clinical condition of the patients more compromised.
Detailed Description
The positive effect of physical training in patients with heart failure (HF) has been increasingly established. However, the presence of atrial fibrillation (AF), mainly in its permanent form, makes the clinical picture of these patients more compromised. The literature has not yet demonstrated studies involving indication of physical exercise therapy when AF is associated with HF. Thus, the hypothesis is that physical training improves functional capacity, cerebral oxygenation, autonomic aspects, vascular aspects, cardiac function, plasma markers, quality of life and cognitive function of these patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with clinically stable NYHA class II to III heart failure with permanent atrial fibrillation (AF);
- •Left ventricular ejection fraction ≤40%;
- •Patients refractory and / or no indication of the treatment of reversal to the rhythm;
- •Patients in optimization specific drug therapy for HF and AF.
Exclusion Criteria
- •High-frequency ventricular response;
- •Neuromuscular / neuropathy disease;
- •Physical and mental impairment;
- •Chronic obstructive pulmonary disease;
- •Diabetes mellitus;
- •Decompensated arterial hypertension;
- •Autonomic neuropathy;
- •Recent myocardial infarction (\<6 months);
- •Ventricular arrhythmias;
- •Atrial flutter;
Outcomes
Primary Outcomes
Functional Capacity Assessement
Time Frame: two year
unctional function is assessed by measuring oxygen consumption (VO2). Multidimensional electrocardiography logo will be connected to a computerized system through a remote and tracheal control system. Through Oxygen Detergent (O2) and carbon dioxide (CO2) the concentrations of O2 and CO2, respectively, are analyzed for each respiratory cycle.
Secondary Outcomes
- Muscle Sympathetic Nervous Activity Assessment(Two year)
- Measurement of Muscle Blood Flow(Two year)
- Evaluation of endothelium-dependent vascular function(Two year)
- Evaluation of neurovascular control during mental stress(Two)
- Evaluation of the concentration of plasma biomarkers(Two year)
- Assessment of cognitive function(Two year)
- Evaluation of cardiac structure and function(Two year)
- Quality of life assessment(Two year)
- Measurement of Pulse Wave Velocity (PWV)(Two year)