Exercise Training in Chagas Cardiomyopathy

Phase 4

Completed

• Conditions: Chagas Disease; Cardiomyopathy; Exercise Training

• Registration Number: NCT01006473
• Lead Sponsor: Federal University of Minas Gerais

Brief Summary

The benefits of exercise training in heart failure are well established. Its effects, however, have not been evaluated in Chagas cardiomyopathy (ChC). The investigators hypothesis is that the exercise training may improve functional capacity, quality of life (QoL), and reduce brain natriuretic peptide (BNP) levels in patients with ChC.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-03
• Primary Completion: 2008-03
• Study Completion: 2009-03
• Study First Submitted: 2009-11-01
• Study First Submitted QC: 2009-11-01
• Study First Posted: 2009-11-01
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-10
• Last Update Posted: 2015-08-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Chronic Chagas dilated cardiomyopathy, defined by the echocardiography finding of a dilated left ventricle with moderate or severe impaired left ventricular systolic function (left ventricular ejection fraction ≤ 45%).
• To be clinically stable for at least 3 months
• To have sinus rhythm
• To be under standard medical therapy use at the time.

Exclusion Criteria

• Inability to attend regular exercise training
• The presence of a pacemaker, associated cardiac or systemic diseases
• Practitioners of regular physical activity

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Health related quality of life	12 weeks
Functional capacity	12 weeks
Functional class	12 weeks
BNP levels	12 weeks

Secondary Outcome Measures

Name	Time	Method
Complications related to the exercise training	12 weeks

Trial Locations

Locations (1)

Federal University of Minas Gerais; 🇧🇷 Belo Horizonte, Minas Gerais, Brazil