Asian neTwork for Translational Research and Cardiovascular Trials ("ATTRaCT")
Completed
- Conditions
- Heart Failure
- Interventions
- Other: Cardiovascular Magnetic Resonance Imaging (CMRI)Other: Electrocardiogram (ECG)Other: Blood Sample CollectionOther: Clinical AssessmentOther: Cardiovascular Ultrasound (CVUS)Other: Cognitive Test
- Registration Number
- NCT02791009
- Lead Sponsor
- National Heart Centre Singapore
- Brief Summary
To build on Singapore's competitive advantages in advanced cardiac imaging, genetic and molecular studies to develop an integrated "one -stop" platform spanning from human to large and small animal models, dedicated to deepening the understanding of CV disease progression, discovery of new targets and repurposing of drugs.
- Detailed Description
Heart failure (HF) is the final common pathway of cardiovascular (CV) diseases and leading cause of CV hospitalizations in Singapore and worldwide, with a mortality rate that rivals most cancers (\>50% mortality at 5 years). Also similar to cancer, HF is a staged disease where early detection and treatment are vital for prevention of disease progression from Stage A (risk factors) to Stage B (subclinical structural heart disease) and Stage C (symptomatic HF). Cardiac imaging is critical for the detection of early subclinical disease. There is limited understanding of the mechanisms underlying disease progression and effective therapies are limited, particularly for the half of the HF population with preserved ejection fraction (HFPEF or "diastolic HF") for which there is no effective therapy to date (in contrast to HF with reduced ejection fraction \[HFREF\] or "systolic HF").
The investigators overall aim is to build on Singapore's competitive advantages in advanced cardiac imaging, genetic and molecular studies to develop an integrated "one -stop" platform spanning from human to large and small animal models, dedicated to deepening the understanding of CV disease progression, discovery of new targets and repurposing of drugs.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 815
Inclusion Criteria
- Age 21-99
- Present to hospital with diagnosis of HF, or
Attending a hospital clinic for management of HF within 6/12 of an episode of decompensated heart failure* which either:
- Resulted in a hospital admission (primary diagnosis) or
- Was treated in out-patient clinic * Appropriate symptoms and signs of HF, confirmed by PI when necessary
Exclusion Criteria
- HF primary due to severe valve disease
- The primary diagnosis is an Acute coronary syndrome (ACS) which has resulted in a transient episode of Acute pulmonary oedema (APO) (Note: Patients with a troponin rise noted during the index admission, but in whom the main presentation is considered clinically to the HF will be included)
- End stage renal failure (eGFR < 15ml/min/m2) or is receiving or planned to receive renal replacement therapy.
- Other specific subgroups of HF (Including constrictive pericarditis, complex adult congenital heart disease, hypertrophic cardiomyopathy, eosinophilic myocarditis, cardiac amyloid and acute chemotherapy-induces cardiomyopathy)
- Isolated right heart failure** (combined right and left heart failure will be included). (Secondary to severe lung disease or pulmonary hypertension)
- Life threatening co-morbidity with a life expectancy of < 1 year
- Inability to provide informed consent
- The patient is unable to comply with study protocol requirements
- The patient is participating in another clinical research trial(only if that study precludes involvement in an observational study)
- The patient has declined to participate
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Diagnosed Heart Failure [Prior] Cardiovascular Ultrasound (CVUS) Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Control [Prior] Cardiovascular Magnetic Resonance Imaging (CMRI) Control will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Control [Prior] Clinical Assessment Control will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Control [New] Cardiovascular Ultrasound (CVUS) Control will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Diagnosed Heart Failure [Prior] Clinical Assessment Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Control [Prior] Electrocardiogram (ECG) Control will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Control [Prior] Cardiovascular Ultrasound (CVUS) Control will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Control [New] Cardiovascular Magnetic Resonance Imaging (CMRI) Control will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Control [New] Electrocardiogram (ECG) Control will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Control [New] Blood Sample Collection Control will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Diagnosed Heart Failure [Prior] Blood Sample Collection Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Control [Prior] Blood Sample Collection Control will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Control [New] Clinical Assessment Control will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Diagnosed Heart Failure [New] Cardiovascular Magnetic Resonance Imaging (CMRI) Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection, Cognitive Test and Clinical Assessment. Diagnosed Heart Failure [New] Blood Sample Collection Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection, Cognitive Test and Clinical Assessment. Diagnosed Heart Failure [Prior] Electrocardiogram (ECG) Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Diagnosed Heart Failure [Prior] Cardiovascular Magnetic Resonance Imaging (CMRI) Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection and Clinical Assessment. Diagnosed Heart Failure [New] Cardiovascular Ultrasound (CVUS) Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection, Cognitive Test and Clinical Assessment. Diagnosed Heart Failure [New] Cognitive Test Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection, Cognitive Test and Clinical Assessment. Diagnosed Heart Failure [New] Electrocardiogram (ECG) Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection, Cognitive Test and Clinical Assessment. Diagnosed Heart Failure [New] Clinical Assessment Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI), Cardiovascular Ultrasound (CVUS), Electrocardiogram (ECG), Blood Sample Collection, Cognitive Test and Clinical Assessment.
- Primary Outcome Measures
Name Time Method First occurrence of cardiovascular event. 3 Year
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
National Heart Centre Singapore
🇸🇬Singapore, Singapore