Evaluation the effects of different doses of Melatonin on pain control after surgery and their effects on the need for opioid and non-opioid analgesics in patients who are candidates for spinal anesthesia
Phase 3
Recruiting
- Conditions
- postoperative pain.Acute pain, not elsewhere classifiedG89.1
- Registration Number
- IRCT20230516058207N1
- Lead Sponsor
- Research Vice-Chancellor of Jundishapur University of Medical Sciences, Ahvaz
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 152
Inclusion Criteria
Be over 18 years old
Candidate patients for spinal anesthesia
Completing the informed consent form
Exclusion Criteria
Patients with liver failure (liver enzymes more than triple the normal limit)
Patients with renal failure (GFR<60)
pregnancy
Patients with brain tumors.
Patients who have a history of neurological and psychological diseases
People who take warfarin
Drug abuse
History of sensitivity to melatonin
The patient's unwillingness to participate in the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intensity of pain. Timepoint: 1, 2, 6, 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale.;Dosage of opioid analgesic after surgery. Timepoint: 1, 2, 6, 12 and 24 hours after surgery. Method of measurement: Calculate the amount of medicine used.;The dosage of non-opioid analgesic after surgery. Timepoint: 1, 2, 6, 12 and 24 hours after surgery. Method of measurement: Calculate the amount of medicine used.
- Secondary Outcome Measures
Name Time Method Side effects include drowsiness, fatigue, confusion, headache, irritability, nausea, vomiting and itching. Timepoint: 1, 2, 6, 12 and 24 hours after surgery. Method of measurement: Ask the patient.