Standard versus Pre-emptive Antibiotic Treatment to Reduce the Rate of Infectious Outcomes after Whipple procedure (SPARROW): a multicenter, randomized controlled trial
Recruiting
- Conditions
- Pancreatic cancer100179901001981510014713
- Registration Number
- NL-OMON56173
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 344
Inclusion Criteria
• Patients undergoing elective pancreatoduodenectomy with a high risk for
contaminated bile defined as patients with preoperative biliary drainage or an
ampullary malignancy.
• Age of 18 years
Exclusion Criteria
• Pregnancy
• Contraindication for the study antibiotics (e.g. allergy or intolerance)
• Indication for endocarditis prophylaxis
• Preoperative planned therapeutic antibiotic treatment after surgery (i.e. for
cholangitis or liver abscesses)
• A reduced renal function, defined as an eGFR of <60 ml/min/1.73m2 measured on
the closest timepoint prior to pancreatoduodenectomy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method