vitamin D and non-alcoholic fatty liver disease
- Conditions
- on-alcoholic fatty liver disease.Fatty (change of) liver, not elsewhere classified
- Registration Number
- IRCT201503163320N10
- Lead Sponsor
- Vice Chancellor for research of Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 72
willingness to participate in the study, 18-50 years old, liver steatosis on sonographic image, vitamin D deficiency(25(OH)D levels less than 30ng/ml), BMI=25
Exclusion criteria: Alcohol consumption(more than 20g/day), menopause, gestation or lactation, BMI>40, diabetes and insulin resistance, any other liver disease(viral disease, Wilson, Hemochromatosis, glycogen storage disorders and etc) or using drugs for the treatment of fatty liver(such as omega-3 and herbal supplements), Thyroid and parathyroid disorders, bone problems, Cushing's syndrome, fat malabsorption, cholecystectomy and any other disease that affect the liver, renal disease(renal failure and nephrolithiasis), using vitamin D, calcium and vitamin E supplements in the past 6 months, taking any drugs causing fatty liver or hepatotoxic drugs(calcium channel blocker,methotrexate,tamoxifen, valproate, diltiazem, amiodarone, isoniazid, corticosteroids and high-dose of estrogen and progestin, and the use of contraceptives), taking drugs affecting insulin resistance and liver function(Such as metformin, pioglitazone, lovastatin and etc.), get weight loss diet in the past 6 months, using total parenteral nutrition in the past 6 months.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum 25(OH)D. Timepoint: Beginning and end of the intervention. Method of measurement: ELIZA.;Serum Adiponectin. Timepoint: Beginning and end of the intervention. Method of measurement: ELIZA.;Liver Enzyme (ALT,AST,ALP). Timepoint: Beginning and end of the intervention. Method of measurement: IFCC.;Liver steatosis. Timepoint: Beginning and end of the intervention. Method of measurement: Liver Sonography.
- Secondary Outcome Measures
Name Time Method Anthropometry. Timepoint: Begining and end of intervention. Method of measurement: Scale and meter and bioelectrical impedance analyzer.;Energy and nutrient intake. Timepoint: Beginning and end of the intervention. Method of measurement: 24- hour dietary recall.;Physical activity. Timepoint: Begining and end of intervention. Method of measurement: Physical activity Questionnaire.;Sun exposure. Timepoint: Begining and end of intervention. Method of measurement: Questionnaire.