Study of Arterial Recanalization of the Central Retinal Artery Occlusions

Completed

• Conditions: Central Retinal Artery Occlusion

• Registration Number: NCT03049514
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke (IS) at the retinal level. They share the same risk factors and common pathology. Their incidence is lower (8.5 / 100,000) and the functional prognosis is unfavorable in 80% of cases with visual acuity (VA) \<1/10. The diagnosis of an CRAO is clinically based on the sudden occurrence of a decrease in deep visual acuity with fundamentally signs of reactive ischemia. There is no data on early retinal arterial recanalization after CRAO, nor on the relationship between early recanalization (spontaneous or post-thrombolysis) and visual prognosis.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-12-23
• Study First Submitted: 2017-02-08
• Study First Submitted QC: 2017-02-08
• Study First Posted: 2017-02-10
• Status Verified: 2022-04
• Primary Completion: 2022-04-02
• Study Completion: 2022-04-02
• Last Update Submitted: 2022-04-07
• Last Update Posted: 2022-04-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Central Retinal Artery Occlusion ≤ 24 hours

Exclusion Criteria

• Retinal Dynamic angiography not performed within 48 hours of onset of symptoms
• Occlusion of a branch of the central retinal artery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dynamic retinal angiography data at 24 hours (+/- 24 hours)	24 hours (+/- 24 hours) following the beginning of symptoms	Proportion of patients with early arterial recanalization.The recanalization rate will be compared between thrombolysed patients and non-thrombolysed patients

Trial Locations

Locations (1)

Fondation ophtalmique Adolphe de Rothschild; 🇫🇷 Paris, France