Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO)

Recruiting

• Conditions: Etiology; Prognosis; Magnetic Resonance Imaging; Diagnosis; Retinal Artery Occlusion

• Registration Number: NCT03313817
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke at the retinal level. They share the same risk factors and common pathology. The diagnosis of a CRAO is clinically based on the sudden occurrence of a decrease in deep visual acuity with fundamentally signs of reactive ischemia.

Small studies have highlighted the value of cerebral MRI (Magnetic Resonance Imaging) in CRAO with almost 25% of ischemic strokes found on diffusion sequences and the demonstration of a correlation between anomalies in diffusion sequence and the probability of a pathology with a high risk of recurrence (carotid stenosis or emboligenic cardiopathy). But there are usually few radiological signs that allow a direct positive diagnosis of CRAO, an etiologic diagnosis or a prognosis. This descriptive study will focus on CRAO at the diagnostic and post-treatment phases in the short and medium term, in order to (i) identify imaging etiologic signs of CRAO with specific sequences from a 3 Tesla MRI, (ii) identify positive diagnostic signs of CRAO with the same specific sequences, (iii) correlate these signs with the visual prognosis one month after the CRAO.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-09-25
• Study First Submitted QC: 2017-10-13
• Study First Posted: 2017-10-18
• Study Start: 2017-12-13
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-10
• Last Update Posted: 2023-07-11
• Primary Completion: 2024-02
• Study Completion: 2024-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• 18 years of age or older
• CRAO (onset of symptoms ≤ 48 hours)
• Consent to participate in the study

Exclusion Criteria

• Contraindications to 3 Tesla MRI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Contrast enhancement of the ophthalmic artery	Baseline	Binary variable (yes/no)
Presence of a thrombus	Baseline	Binary variable (yes/no)
Restriction of the apparent diffusion coefficient (ADC) at the optic nerve level and at the papilla level	Baseline	Binary variable (yes/no)
Hypersignal of the ophthalmic artery in diffusion	Baseline	Binary variable (yes/no)
Presence of an arterial stenosis of the supra aortic trunks	Baseline	Binary variable (yes/no)

Trial Locations

Locations (1)

Fondation Ophtalmologique A. de Rothschild; 🇫🇷 Paris, France