Effect of Green Light Exposure at Different Times on the Pain of Subjects

Not Applicable

Not yet recruiting

• Conditions: Pain

• Registration Number: NCT07033949
• Lead Sponsor: The Second Affiliated Hospital of Chongqing Medical University

Brief Summary

Patients who met the criteria and needed to undergo elective surgery via arterial and venous puncture were included in this center. They were randomly divided into three time periods (8:00-9:00, 12:00-13:00, 16:00-17:00) and were exposed to green light (experimental group) and transparent light (control group) respectively. The effects of green light exposure on acute perioperative pain in patients were observed at different times.

Detailed Description

Random numbers were generated by the computer to randomly assign patients who met the inclusion and exclusion criteria to the experimental group (exposed to green light) and the control group (exposed to transparent light). The patients were randomly assigned to three time periods (8:00-9:00, 12:00-13:00, 16:00-17:00) to receive a colored exposure with glasses: Therefore, in order to minimize bias and expectations, it was not informed to the patients which color would affect the pain during the arterial puncture. The patients rested in the pre-anesthesia room for 5 minutes, their heart rate (HR) was measured, and a pain sensitivity test (tender point) was conducted. Then, the patients wore the trial glasses and stayed in the pre-anesthesia room for 30 minutes, and they underwent arterial and venous punctures. While monitoring the patients' heart rate, the catheterization of the arterial and venous punctures was performed. Then, during the arterial and venous puncture, their pain scores (NRS) were recorded separately.

exposed to green light (green group) for 30 minutes. The above operation will be repeated to measure the patient's pain threshold.

Study Timeline

• Status Verified: 2025-06
• Study First Submitted: 2025-06-15
• Study First Submitted QC: 2025-06-15
• Study First Posted: 2025-06-24
• Last Update Submitted: 2025-06-24
• Last Update Posted: 2025-06-27
• Study Start: 2025-07-01
• Primary Completion: 2025-10-19
• Study Completion: 2025-10-19

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. Age range: 18 - 50 years old.
2. ASA classification: I - III.
3. Planned to undergo abdominal surgeries requiring general anesthesia and arterial puncture (this is not necessary for the healthy volunteer group).
4. Obtained informed consent from the patients.

Exclusion Criteria

1. Skin ulceration, allergic reactions, or dermatitis at the tested area.
2. Long-term use of analgesics or psychiatric medications.
3. History of color blindness or uncorrected cataracts.
4. Severe cardiovascular or respiratory diseases, inflammatory disorders, etc.
5. Failure of the first arterial puncture.
6. Communication difficulties, etc.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Pain intensity during arteriovenous puncture	The pain score during arterial puncture which about 2-3min	assessed using number rating scale (0 to 10, which higher scores mean a worse pain intensity)

Secondary Outcome Measures

Name	Time	Method
Pain sensitivity	from the time before to 30 min after light exposure	assessed by pressure pain stimulation (magnitude of pressure, kilogram per square centimeter)
Analgesic consumption during surgery	From surgery beginning to the ending of the surgery	assessed by the actual dose of analgesic during the surgery
Pain intensity after surgery	From ending of the surgery to 24 hours after surgery	assessed using number rating scale (0 to 10, which higher scores mean a worse pain intensity)
Analgesic consumption after surgery	From ending of the surgery to 24 hours after surgery	assessed by the actual dose of analgesic after surgery

Trial Locations

Locations (1)

The Second Affiliated Hospital of Chongqing Medical University; 🇨🇳 Chongqing, Chongqing, China