Nasal Humidified High Flow Oxygen During Weaning From Mechanical Ventilation : Ultrasonography Study

Not Applicable

Completed

• Conditions: Consent of Patients; Arterial Line; Adult Patients Ventilated More Than 48 h; Stable Respiratory and Hemodynamic Conditions for SBT
• Interventions: Other: mechanical ventilation

• Registration Number: NCT01702779
• Lead Sponsor: University Hospital, Clermont-Ferrand

Brief Summary

This is a prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

Detailed Description

Prospective randomized clinical multicentric study on ICU (Intensive Care University) comparing nasal humidified high flow therapy versus standard oxygen with Lung Ultrasound Score during weaning from mechanical ventilation

Study Timeline

• Study Start: 2011-08
• Study First Submitted: 2012-04-24
• Study First Submitted QC: 2012-10-05
• Study First Posted: 2012-10-08
• Primary Completion: 2013-06
• Study Completion: 2013-06
• Status Verified: 2014-11
• Last Update Submitted: 2014-11-28
• Last Update Posted: 2014-12-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Adult patients ventilated more than 48 h
• Stable respiratory and hemodynamic conditions for SBT
• Consent of patients
• Arterial line

Exclusion Criteria

• COBP
• Laryngeal dyspnea
• Tracheostomy
• Arythmya
• No echogenicity
• Paraplegia >T8

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
optiflow	mechanical ventilation	-
O2	mechanical ventilation	-

Primary Outcome Measures

Name	Time	Method
variations of lung ultrasound score	24 hours after extubation

Secondary Outcome Measures

Name	Time	Method
Lung ultrasound score	at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation
rates of patients with postextubation distress	during the 48th post-extubation
Electrical Impedance tomography	at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation
Epithelial and endothelial biomarkers	at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation

Trial Locations

Locations (1)

CHU Clermont-Ferrand; 🇫🇷 Clermont-Ferrand, France