Efficacy of midazolam and dexmedetomidine for attenuating the hormonal stress response to endotracheal intubation in hypertensive adult patients undergoing elective surgery.
Phase 3
Recruiting
- Conditions
- Anaesthesia
- Registration Number
- PACTR201909641727181
- Lead Sponsor
- eman sayed
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
ASA physical status II & III, aged 18–65 years, scheduled for elective surgery, and known to be hypertensive with good control ( blood pressure lower than 140/90), were included in the study.
Exclusion Criteria
Patients were excluded if they have known allergy to any of the study drugs, arterial blood pressure more than 140/90, preoperative arrhythmias, tachycardia (heart rate > 100 beats per minute), bradycardia (heart rate < 50 beats per minute), second- or third-degree atrioventricular block, coronary artery disease, , previous cerebrovascular accident, renal or liver impairment, obesity (body mass index>30), and suspected difficult intubation.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the hemodynamics which includes mean arterial blood pressure (MABP) and heart rate (HR)
- Secondary Outcome Measures
Name Time Method biochemical end point through serum cortisol and serum norepinephrine level measurement (reflecting the magnitude of the hormonal stress responses