Bariatric procedures and changes in incretines and gastric emptying

Recruiting

• Conditions: Gastric emptying; Hormonal changes; Transit time; 10017998

• Registration Number: NL-OMON40704
• Lead Sponsor: Rijnstate Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

I.
Patients who are approaching their two years follow-up after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) and Laparoscopic Sleeve Gastrectomy (LSG) are eligble for inclusion. The patients will be arranged in one of the following four groups according to the Reinhold*s criteria:;- Good responders (EWL > 50%) two years after RYGB
- Bad responders (EWL < 25%) two years after RYGB
- Good responders (EWL > 50%) two years after LSG
- Bad responders (EWL < 25%) two years after LSG;II.
Patients who are eligble for duodenal-jejunal bypass liner implantation. These patients have been diagnosed with type 2 and a BMI 28-45 kg/m2.

Exclusion Criteria

- Binge-eating or associated eating disorder
- Active drug or alcohol addiction
- Gluten allergy
- Inability to stop medication that affects the motility of the upper gastrointestinal tract (anti-cholinergic drugs, prokinetics, theophylline, calcium blocking agents, opioids)
- Endocrine disease influencing gastric emptying (diabetes mellitus, hyper- or hypothyroidism). T2DM is not an exclusion criteria for patients receiving the DJBL because T2DM is a requirement for receiving the DJBL. Additionally, changes in GE rate will be determined 1 month after implantation. No significant changes in GE rate will be expected in this time period caused by their T2DM

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Gastric emptying rate and incretin levels two years after LRYGB and LSG, and<br /><br>gastric emptying before and 1 month after DJBL implantation.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Weight loss/ excess weight loss two years after Roux-en-Y Gastric Bypass and<br /><br>Sleeve Gastrectomy<br /><br>- Quality of life two years after Roux-en-Y Gastric Bypass and Sleeve<br /><br>Gastrectomy<br /><br>- Quality of life before and one month after implantation of the<br /><br>duodenal-jejunal bypass liner</p><br>