Marine n-3 Polyunsaturated Fatty Acids in Pre- and Postmenopausal Women

Not Applicable

Completed

• Conditions: Postmenopause; Premenopause
• Interventions: Dietary Supplement: marine n-3 polyunsaturated fatty acids; Dietary Supplement: Thistle oil

• Registration Number: NCT00901589
• Lead Sponsor: Aalborg University Hospital

Brief Summary

The study is a randomised placebo controlled double-blinded clinical trial where a group of healthy pre- and postmenopausal women is randomised to the intake of fish oil capsules or placebo oil capsules for 12 weeks. Anthropometric measurements(weight, height,blood pressure) blood samples and adipose tissue biopsies will be taken in order to illustrate the effect of marine n-3 PUFAs (fish oil) on the concentration of circulating female hormones and to investigate what impact menopause might have on the ability to incorporate marine n-3 PUFAs into tissues.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-08
• Status Verified: 2009-05
• Primary Completion: 2009-05
• Study Completion: 2009-05
• Study First Submitted: 2009-05-13
• Study First Submitted QC: 2009-05-13
• Last Update Submitted: 2009-05-13
• Study First Posted: 2009-05-14
• Last Update Posted: 2009-05-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 92

Inclusion Criteria

• age 18-70 years old
• healthy or well-treated chronic disease

Exclusion Criteria

• hormone treatment
• foreseen compliance problem
• fish oil consumers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Premenopausal women-fishoil	marine n-3 polyunsaturated fatty acids	-
Premenopausal-placebo	Thistle oil	-
Postmenopausal women-fishoil	marine n-3 polyunsaturated fatty acids	-
Postmenopausal-placebo	Thistle oil	-

Primary Outcome Measures

Name	Time	Method
Content of marine n-PUFAs as percent of total content of fatty acids in adipose tissue and in platelets before and after intervention

Secondary Outcome Measures

Name	Time	Method
Measurement of oestrogen concentrations in blood before and after intervention

Trial Locations

Locations (1)

Center for cardiovascular research, Aalborg Hospital; 🇩🇰 Aalborg, Denmark