Can electrical stimulation of muscles be used to improve walking for people with Parkinson’s disease?

Not Applicable

Completed

• Conditions: Specialty: Dementias and neurodegeneration, Primary sub-specialty: Parkinson's Disease; UKCRC code/ Disease: Neurological/ Other disorders of the nervous system; Nervous System Diseases; Parkinson's disease

• Registration Number: ISRCTN17609599
• Lead Sponsor: Salisbury NHS Foundation Trust

Brief Summary

Preprint results see attached file 33440 preprint results.pdf (added 12/08/2022) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/33826449/ (added 12/08/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-04-05
• Study Completion: 2018-04-30
• Last Update Posted: 29 August 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

1. Aged 18 years and above (no upper age limit)
2. Idiopathic Parkinson’s disease
3. Hoehn and Yahr stages I to IV under medication
4. Difficulty with gait (clinical observation by experienced clinician):
4.1. Reduced dorsiflexion or eversion at any point in the swing or weight acceptance phase of gait,
4.2. Bradykinesia demonstrated by a measured 10m walking speed of less than 1.25ms-1
4.3. Festination demonstrated by walking with short rapid strides
4.4. Akinesia demonstrated by exhibiting freezing episodes while walking. This may be in restricted areas such as doorways.
4.5. Hypokinesia demonstrated by walking with a short stride length
5. Able to walk 10m with appropriate walking aids but without assistance from another person
6. Able to obtain standing from sitting without the assistance of another person.
7. Medically stable defined as no significant changes in the participants condition over the last 3 months
8. Able to understand and comply with the treatment and assessment procedures
9. Able to give informed consent
10. Able to start using FES within 2 weeks

Exclusion Criteria

1. Able to walk 10m in less than 8s (walking speed >1.25ms-1) indicating non limited functional walking
2. Other treatment than standard drug therapy (FES, deep brain stimulation, duodopa, apomorphine)
3. Atypical or secondary parkinsonism or parkinsonism related to other neurodegenerative diseases
4. Dropped foot due to any neurological condition other than Parkinson’s Disease
5. Untreated or refractory epilepsy
6. Pregnancy
7. Cardiac pacemaker, or other active medical implanted devices
8. Denervation of the common peroneal nerve
9. Malignancy or dermatological conditions in the area of the electrodes
10. Major cognitive impairment or dementia

Study & Design

• Study Type: Interventional
• Study Design: Not specified