comparison of ropivacaine (a local anesthetic) and dexmedetomidine when given through nebulisation (steam vapours) on the heart rate and blood pressure during start of surgery under general anesthesia

Completed

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2022/07/044029
• Lead Sponsor: Dr B R Ambedkar State Institute of Medical Sciences

Brief Summary

Sympathetic stimulation due to laryngoscopy and endotracheal intubation results in hemodynamic fluctuations both at intubation as well as extubation. This unwanted hemodynamic response may have deleterious effects in some patients. Various methods are employed for suppression of hemodynamic pressor response at intubation eg iv opioids, alpha agonists, lignocaine etc but at the expense of systemic effects. We will use long acting local anaesthetic ropivacaine 0.75% and alpha agonist dexmedetomidine through ultrasonic nebulisation for direct local action of the drug in the airway.

Total 180 patients will be enrolled for this randomised double blinded placebo controlled study.

The primary objective of the study will be to compare the hemodynamic response of nebulised ropivacaine 0.75% with nebulised dexmedetomidine and with saline during intubation in patients undergoing surgery under general anesthesia. hemodynamic response at extubation , cough response grading and post operative sore throat will also be observed.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-20
• Study Completion: 2023-01-14
• Last Update Posted: 2023-02-02

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

• 1.American Society of Anesthesiologists (ASA) physical status I.
• II 2.Age – 18-60 years 3. Scheduled to undergo elective surgery of duration < 2 hours under general anaesthesiaÂ.

Exclusion Criteria

• 1.Patient with pre operative sore throat or upper respiratory tract infection 2.Patients with history of allergy to local anesthestics 3.Patents with history of allergy to Dexmedetomidine 4.Patients with history of cardiac, liver or renal disorders.
• Patient with anticipated difficult airway with anticipated duration of laryngoscopy > 15 seconds 6.
• patients who refuse to participate.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the hemodynamic response of nebulised ropivacaine 0.75% with nebulised dexmedetomidine and with saline during intubation in patients undergoing surgery under general anesthesia.Â	before and after nebulisation, before intubation, at the time of intubation and 5 minutes after intubation

Secondary Outcome Measures

Name	Time	Method
To compare the hemodynamic parameters at extubation.
To compare cough response after extubation	0 ,5 and 30 minutes
to assess for post operative sore throat	0,2,4,6,12,24 hours

Trial Locations

Locations (1)

Dr B R Ambedkar State Institute of Medical Sciences; 🇮🇳 Rupnagar, PUNJAB, India

Dr B R Ambedkar State Institute of Medical Sciences

🇮🇳Rupnagar, PUNJAB, India

Dr Ravneet Kaur Gill

Principal investigator

9501988361

drravneetkgill@gmail.com