Mitochondrial muscle health and muscle function in elderly
Completed
- Conditions
- VerouderingAgingweakening10028302
- Registration Number
- NL-OMON50517
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 152
Inclusion Criteria
Age: between 20 and 30 years (healthy control group) or between 65 and 80 years
(elderly groups)
BMI: between 20-30 kg/m2
Exclusion Criteria
Diagnosed for diabetes mellitus
Contraindications for MRI scan
Poor health as judged by the responsible medical doctor.
Heart problems: In case of an abnormal ECG in rest, this will be discussed with
both the participant and the responsible medical doctor.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* Maximal aerobic capacity<br /><br>* Resting and exercise energy metabolism<br /><br>* In vivo mitochondrial capacity<br /><br>* Mitochondrial metabolism (markers)<br /><br>* Ex vivo skeletal muscle mitochondrial function (O2-flux pmol mg-1 s-1)<br /><br>* Skeletal muscle DNA, mRNA and protein levels of markers in the mitochondrial<br /><br>biogenesis, function and metabolism *</p><br>
- Secondary Outcome Measures
Name Time Method <p>* Body composition and muscle mass<br /><br>* Physical performance<br /><br>* Intramuscular lipids/acetyl-carnitine<br /><br>* Dynamic gait stability<br /><br>* Muscle strength<br /><br>* Activity monitoring<br /><br>* Insulin sensitivity<br /><br>* Quality of Life<br /><br>* Non invasive bio-markers</p><br>