Low Dose Effects of X-rays in Pediatric Patients Undergoing a CT Examination.

Completed

• Conditions: Pediatric Patients Undergoing a Computed Tomography Examination
• Interventions: Procedure: Blood test

• Registration Number: NCT01518673
• Lead Sponsor: University Ghent

Brief Summary

Patients undergoing a computed tomography are exposed to a relatively high dose of X-rays. Pediatric patients are known to be very radiosensitive with respect to radiation induced cancer. Using the technique of scoring γ-H2AX foci in peripheral blood lymphocytes the most important lesions to the genetic material DNA, double strand breaks induced by CT X-rays can be detected. The technique will be applied in a multicenter setting for evaluation of X-effects induced by a computed tomography examination in a population of pediatric patients. To this end a blood sample will be taken from the patients before and after the examination.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-01-20
• Study First Submitted QC: 2012-01-25
• Study First Posted: 2012-01-26
• Study Start: 2012-02
• Primary Completion: 2015-01
• Study Completion: 2015-06
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-18
• Last Update Posted: 2021-11-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

• pediatric patients wearing a catheter

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
X-rays	Blood test	-

Primary Outcome Measures

Name	Time	Method
X-ray induced genetic effects in pediatric patients directly after a computed tomography scan.	Within 30 min after the computed tomography examination.	Assessment of γ -H2AX foci in peripheral blood lymphocytes.

Trial Locations

Locations (1)

University Hospital Ghent; 🇧🇪 Ghent, Belgium