Inflammatory response of low dose colchicine in patients with ST elevation myocardial infarction and PCI at Surin Hospital
Phase 4
Recruiting
- Conditions
- patient 18-80 years admitted at Surin hospital which ST elevation myocardial infarction and percutaneous coronary intervention .Colchicine , ST elevation myocardial infarction , Percutaneous Coronary Intervention .
- Registration Number
- TCTR20210127002
- Lead Sponsor
- Surin hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
patients presented at Surin hospital with known case ST elevation myocardial infarction ( STEMI) and received percutaneous coronary intervention ( PCI).
Exclusion Criteria
1.Pregnancy, 2.Breast feeding,3.active inflammation, 4. infectious disease, 5.current treatment of corticosteroids or other inflammatory agents, 6.hypersensitivity for colchicine, 7.chronic treatment of colchicine,8.chronic diarrhea, 9.colchicine intolerance or contraindication,10.severe renal failure, 11.hepatic failure ( Chid-Puge class B,C),12. cardiac arrest, 13.cardiogenic shock,14.heart failure NYHA class 3,4, 13. inability or unwilliness to provide informed consent.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method level of CKMB, hsTroponin I,CRP at 14 days after end of the intervention Enzymatic immuno-inhibition test for CKMB,Chemiluminescent immunoassay for hs Troponin I,
- Secondary Outcome Measures
Name Time Method V ejection fraction 14 days Echocardiography evaluate LV function by modified bi-plane technique