Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos

• Conditions: Mesothelioma; Lung Cancer

• Registration Number: NCT01719068
• Lead Sponsor: British Columbia Cancer Agency

Brief Summary

This is a pilot study that aims to develop a lung cancer screening program for workers in British Columbia, Canada exposed to asbestos who are at risk of developing lung cancer/pleural mesothelioma. This is high risk population is at of respiratory system diseases as a result of their occupational exposures. Additionally, knowledge garnered from this study will allow us to develop other studies that will further our understanding of asbestos related lung cancer and mesothelioma.

Detailed Description

Not available

Study Timeline

• Status Verified: 2012-10
• Study Start: 2012-10
• Study First Submitted: 2012-10-30
• Study First Submitted QC: 2012-10-30
• Last Update Submitted: 2012-10-30
• Study First Posted: 2012-11-01
• Last Update Posted: 2012-11-01
• Primary Completion: 2014-10
• Study Completion: 2014-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Women or men age 50 to 79 years

• history of exposure to asbestos at work and one or more of the following:

  • lung cancer risk ≥2% over 3 years or
  • asbestosis or pleural plaques on a chest x-ray or
  • abnormal auto-antibodies level using the EarlyCDT test

• Capable of providing informed consent for screening procedures (low dose spiral CT, lung function, blood biomarkers).

Exclusion Criteria

• Any medical condition, such as severe heart disease (e.g. unstable angina, chronic congestive heart failure), acute or chronic respiratory failure, or any disorder, that in the opinion of the physician unlikely to benefit from screening due to shortened life-expectancy from co-existing illnesses
• Have been previously diagnosed with mesothelioma
• Have had other cancer within the past 5 years with the exception of the following cancers: non-melanomatous skin cancer,localized prostate cancer, carcinoma in situ (CIS) of the cervix, or superficial bladder cancer. Treatment of the exceptions must have ended >6 months before registration into this study
• Pregnancy
• Unwilling to have a low dose CT scan of chest
• Unwilling to sign a consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Development of Model to Predict Workers at highest risk of lung cancer/mesothelioma	3 years

Trial Locations

Locations (1)

British Columbia Cancer Agency; 🇨🇦 Vancouver, British Columbia, Canada