Association Between Carotid Plaque Length and Cardiovascular Outcomes

Active, not recruiting

• Conditions: Coronary Artery Disease; Carotid Plaque

• Registration Number: NCT05843487
• Lead Sponsor: Changhai Hospital

Brief Summary

This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No. 904 Hospital of the PLA Joint Logistics Support Force Wuxi). The study enrolled 5000 consecutive patients without known CAD who underwent first coronary angiography for stable chest pain and carotid ultrasound was performed during hospitalization from January 2017 through December 2018.

Detailed Description

Patients who had obstructive CAD (defined as ≥50% luminal stenosis) confirmed by coronary angiography and who underwent carotid scanning were included in the final analysis.Carotid ultrasonography was performed simultaneously, and carotid intima-media thickness (IMT), maximum thickness and length of all plaques were measured.The incidence of major adverse cardiovascular events was recorded during follow-up.

Study Timeline

• Study Start: 2017-01-01
• Primary Completion: 2022-03-31
• Status Verified: 2022-06
• Study First Submitted: 2023-04-25
• Study First Submitted QC: 2023-04-25
• Last Update Submitted: 2023-04-25
• Study First Posted: 2023-05-06
• Last Update Posted: 2023-05-06
• Study Completion: 2030-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

• Patients who underwent coronary angiography for stable chest pain and carotid ultrasound simultaneously;
• Patients with obstructive CAD (≥50% coronary stenosis);

Exclusion Criteria

• <18 years of age;
• previous carotid surgery or significant carotid artery disease;
• prior stroke or transient ischemic attack;
• previously documented CAD (including history of myocardial infarction, acute coronary syndrome, or coronary revascularization);

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
major adverse cardiovascular events	3 years	cardiovascular death, myocardial infarction, ischemic stroke and coronary revascularization

Secondary Outcome Measures

Name	Time	Method
cardiovascular death	3 years
ischemic stroke	3 years
heart failure	3 years
all-cause death	3 years
myocardial infarction	3 years
coronary artery revascularization	3 years

Trial Locations

Locations (5)

Gongli Hospital; 🇨🇳 Shanghai, Shanghai, China

No. 904 Hospital of the PLA Joint Logistics Support Force; 🇨🇳 Wuxi, Jiangsu, China

Changhai Hospital; 🇨🇳 Shanghai, Shanghai, China

Putuo Hospital; 🇨🇳 Shanghai, Shanghai, China

Yueyang Hospital; 🇨🇳 Shanghai, Shanghai, China