Association Between Carotid Plaque Length and Cardiovascular Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 3,000
- 试验地点
- 5
- 主要终点
- major adverse cardiovascular events
研究概览
简要总结
This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No. 904 Hospital of the PLA Joint Logistics Support Force Wuxi). The study enrolled 5000 consecutive patients without known CAD who underwent first coronary angiography for stable chest pain and carotid ultrasound was performed during hospitalization from January 2017 through December 2018.
详细描述
Patients who had obstructive CAD (defined as ≥50% luminal stenosis) confirmed by coronary angiography and who underwent carotid scanning were included in the final analysis.Carotid ultrasonography was performed simultaneously, and carotid intima-media thickness (IMT), maximum thickness and length of all plaques were measured.The incidence of major adverse cardiovascular events was recorded during follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent coronary angiography for stable chest pain and carotid ultrasound simultaneously;
- •Patients with obstructive CAD (≥50% coronary stenosis);
排除标准
- •<18 years of age;
- •previous carotid surgery or significant carotid artery disease;
- •prior stroke or transient ischemic attack;
- •previously documented CAD (including history of myocardial infarction, acute coronary syndrome, or coronary revascularization);
结局指标
主要结局
major adverse cardiovascular events
时间窗: 3 years
cardiovascular death, myocardial infarction, ischemic stroke and coronary revascularization
次要结局
- cardiovascular death(3 years)
- ischemic stroke(3 years)
- heart failure(3 years)
- all-cause death(3 years)
- myocardial infarction(3 years)
- coronary artery revascularization(3 years)