Pre- vs. postoperative thromboprophylaxis for liver resection – a prospective, multicenter, randomized controlled trial

Phase 1

• Conditions: Venous thromboembolism; Therapeutic area: Diseases [C] - Blood and lymphatic diseases [C15]

• Registration Number: EUCTR2019-002323-15-NO
• Lead Sponsor: Helsinki University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-03-29
• Last Update Posted: 13 December 2021

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: 1012

Inclusion Criteria

All patients undergoing liver resection
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 160
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 240

Exclusion Criteria

Patient on anticoagulative medication (heparin, low-molecular weight heparin, warfarin, direct oral anticoagulants) during last month pre-surgery
Emergency operation (e.g. for trauma or infection)
Age < 18 years
Allergy or other contraindication to planned low-molecular weight heparin
Inability to give written informed consent
Liver resection not performed (removed from analyses after randomization)

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified