Efficacy and safety of Thromboprophylaxis in Critically Ill Medical Patients: A Prospective, single centre study

Conditions: venous thromboembolismDeep vein thrombosisPulmonary embolismcritical illness
venous thromboembolism
Deep vein thrombosis
Pulmonary embolism
pharmacological thromboprophylaxis
mechanical thromboprophylaxis

Registration Number: TCTR20230927002

Lead Sponsor: Faculty of Medicine, Chiang Mai University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending (Not yet recruiting)

Sex: All

Target Recruitment: 462

Inclusion Criteria

1. age over 18 year old
2. following indication
a.admit in critical care unit
b.at least 1 condition below
i.respiratory failure, need for mechanical ventilator
ii.Acute kidney injury impending to renal replacement therapy
iii.sepsis which SOFA score over 2 (reference from The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
iv.hemodynamic unstable

Exclusion Criteria

1.taken anticoagulant during study
2.history of thrombophilia
3.undergone major operation 3 months prior to study

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
VTE incidence of the pre-implementation period from admission to 30 days after discharge official doppler ultrasound by radiologist, CT pulmonary angiogram and other imaging modalities as clinical suggestion,VTE incidence of the post-implementation period from admission to 30 days after discharge official doppler ultrasound by radiologist, CT pulmonary angiogram and other imaging modalities as clinical suggestion,incidence of adverse event from thromboprophylaxis from admission to 30 days after discharge observation, physical examination, Lab parameter

Secondary Outcome Measures

Name	Time	Method
VTE associated factors from admission to 30 days after discharge patients outcome record, statistical analysis,sensitivity, specificity, accuracy of predictive VTE score from admission to 30 days after discharge Padua, Caprini, IMPROVE VTE score,Time to VTE event from admission to 30 days after discharge observation, serial ultrasound, imaging modalities,death from admission to 30 days after discharge observe,Length of ICU stay from admission to discharge date observation