Comparison Among Propofol, Alfentanil and Rocuronium as Adjunct to Sevoflurane Anesthesia for Endotracheal Intubation in Children With Frenectomy

Not Applicable

Completed

• Conditions: Ankyloglossia
• Interventions: Drug: administration of propofol; Drug: administration of alfentanil; Drug: administration of rocuronium

• Registration Number: NCT01550354
• Lead Sponsor: Yonsei University

Brief Summary

Several methods have been demonstrated to improve intubating conditions during sevoflurane induction in children. These include opioids, propofol, and addition of neuromuscular blocking agents in pediatric patients. But the study about the comparison of these agents has been uncommon. Frenectomy is common procedure to treat ankyloglossia. It is a short procedure performed under general anesthesia. The investigators aimed to compare intubating conditions among children with propofol, alfentanil or rocuronium after sevoflurane induction.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-02
• Study First Submitted: 2012-02-22
• Study First Submitted QC: 2012-03-06
• Study First Posted: 2012-03-12
• Primary Completion: 2014-01
• Study Completion: 2014-01
• Status Verified: 2021-06
• Last Update Submitted: 2021-06-03
• Last Update Posted: 2021-06-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 114

Inclusion Criteria

• Children, 1-9 years old scheduled elective frenectomy under general anesthesia

Exclusion Criteria

• Patients with an abnormal airway, reactive airway disease, gastroesophageal reflux disease, chronic respiratory disease, or a history of an upper respiratory tract infection in the preceding 6-week period

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Propofol group	administration of propofol	Intravenous administration of propofol 2 mg/kg before intubation
Alfentanil group	administration of alfentanil	Intravenous administration of alfentanil 14 μg/kg before intubation
Rocuronium group	administration of rocuronium	Intravenous administration of rocuronium 0.3 mg/kg before intubation

Primary Outcome Measures

Name	Time	Method
Intubating condition	Participants will be followed for the duration of intubation, an expected average of 1 minute.	The investigators will perform the evaluation of intubating condtion through scoring system provided by Viby-Mogensen during intubation procedure. The scoring system is consisted of excellent, good, and poor.

Trial Locations

Locations (1)

Severance hospital; 🇰🇷 Seoul, Korea, Republic of