Featuring Treated Hypertensive Patients Who Improve Endothelial Function After Dark Chocolate
概览
- 阶段
- 4 期
- 干预措施
- 未指定
- 疾病 / 适应症
- Hypertension
- 发起方
- Hospital Universitario Pedro Ernesto
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Endothelial function
- 状态
- 已完成
- 最后更新
- 14年前
概览
简要总结
We aimed to identify clinical and vascular parameters of treated hypertensive patients who present beneficial effects of dark chocolate for one-week period on vascular function.
详细描述
Recent findings indicate an inverse relationship between cardiovascular disease and consumption of flavonoids. We aimed to identify clinical and vascular parameters of treated hypertensive patients who present beneficial effects of dark chocolate for one-week period on vascular function. Twenty-one hypertensive patients in drug therapy, both genders, aged 40-65 years, were included in a prospective study with measurement of blood pressure, brachial flow-mediated dilatation (FMD), peripheral arterial tonometry (EndoPAT) and central hemodynamic parameters by SphygmoCor. After seven days of eating dark chocolate (70% cocoa) 75g/day, the clinical and vascular evaluation were repeated. Patients were divided into two groups according to the response in FMD: responders (increase in FMD, n=12) and non-responders (no improvement in FMD, n=9).
研究者
Mario Fritsch Neves
Associate Professor
Hospital Universitario Pedro Ernesto
入排标准
入选标准
- •Previous diagnosis of hypertension
- •Use of one or two antihypertensive drugs
- •Systolic blood pressure between 130 and 160 mmHg
- •Diastolic blood pressure between 85 and 100 mmHg
排除标准
- •Secondary hypertension
- •Diabetes mellitus
- •Body mass index \> 35kg/m2
- •Chronic kidney disease
- •Known coronary artery disease
- •Previous stroke
结局指标
主要结局
Endothelial function
时间窗: One week
Endothelial function evaluated by peripheral arterial tonometry and by flow-mediated dilation of brachial artery
次要结局
- Blood pressure(One week)
- Central hemodynamic parameters(One week)