A Study to Evaluate the Efficacy of Intravenous Magnesium in the Management of Atrial Fibrillation with a Rapid Ventricular Rate in the Emergency Department

Phase 4

Recruiting

• Conditions: Atrial Fibrillation; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12619000532101
• Lead Sponsor: Eastern Health Foundation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-04-03
• Last Update Posted: 23 March 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Greater than or equal to 18 years of age
2. ECG at presentation to Emergency Department greater than or equal to a ventricular rate of 120
3. Presenting complaint attributable to atrial fibrillation
4. Able to give informed consent

Exclusion Criteria

1. Haemodynamically instability, in this study, defined as Systolic Blood Pressure less than 90mmHg
2. Suspected acute myocardial infarction
3. Overt sepsis suspected by treating clinician
4. Known renal impairment (egfr <30)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary Outcome - Proportion of participants with a reduction of ventricular rate to <100 beats per minute or greater than 20% from initial heart rate at presentation. Note the primary timepoint shall be 1 hour post initiation of intervention/placebo. <br><br>It is worth noting our secondary outcomes and their associated timepoints. <br><br>Instrument to measure the primary outcome – Heart rate data shall be collected by the following;<br><br>(a) Departmental electrocardiogram every 30minutes for the first hour following commencement of the intervention then hourly thereafter (b) Telemetry (c) Routine nursing observations, at least hourly whilst in the Emergency Department <br><br><br>[Primary Timepoint – 1 hours following initiation of intervention]