Cryopreservation of prepubertal testicular tissue for future autologous transplantation of spermatogonial stem cells: preserving fertility in young boys with cancer
Completed
- Conditions
- Cancer1002765510013356
- Registration Number
- NL-OMON39737
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
- Young patients with cancer (up till 15 years of age)
- Scheduled to undergo cytotoxic treatment with risk of future infertility
- Unable to produce spermatozoa containing semen
Exclusion Criteria
- Malignancies located in the testis (suspicion of metastases of for example lymphomas)
- history of bilateral cryptorchidism or testicular torsion
- ability to ejaculate vital spermatozoa.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Successful sampling and storage of testicular tissue (cryosurvival of SSCs,<br /><br>ability to propagate SSCs in vitro).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Long-term follow-up of possible side-effects of the testicular biopsy in the<br /><br>boy (local defects, endocrine and exocrine function of the remaining testis),<br /><br>post-pubertal fertility (as determined by semen analysis). </p><br>