Portal Hypertension and Liver Resection in Patients With Hepatocellular Carcinoma
- Conditions
- Primary Liver Cancers
- Interventions
- Procedure: Liver resection
- Registration Number
- NCT02145013
- Lead Sponsor
- Henri Mondor University Hospital
- Brief Summary
According to the BCLC guidelines, surgical resection of hepatocellular carcinoma complicating cirrhosis is restricted to patients with preserved liver function, single nodule without vascular invasion and with hepatic venous gradient below 10 mmHg.
However, other guideline treatment, especially from eastern countries demonstrated that surgical resection is safe and feasible and provides better survival than the treatment recommended by the BCLC system for patients with similar stage.
The primary goal of this study is to assess the impact of HVPG on short and long-term outcomes in HCC patients who undergo liver resection.
- Detailed Description
Patients with HCC and candidates for hepatectomy are classified into two groups according to the presence of portal hypertension. Short- and long-term outcomes will be compared.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description No portal hypertension Liver resection Hepatectomy Portal hypertension Liver resection Hepatectomy
- Primary Outcome Measures
Name Time Method Mortality 90 day In-hospital or 90-day mortality
- Secondary Outcome Measures
Name Time Method morbidity 90 day Overall and liver-related complications including liver failure, ascites, biliary fistula, bleeding, pulmonary complications, and renal complications.
Grading system according to Clavien-Dindo classificationSurvival outcomes 1,3 and 5 years Including Overall survival and disease free survival
Trial Locations
- Locations (1)
Henri Mondor University Hospital
🇫🇷Creteil, France