Creatine on Bone Mass in Postmenopausal Women
Not Applicable
- Conditions
- Postmenopausal Women
- Interventions
- Dietary Supplement: dextrose (placebo)Dietary Supplement: Creatine supplementation
- Registration Number
- NCT01472393
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
Animal, in vitro and small-scale studies have suggested that creatine supplementation may augment bone mass. This clinical trial aims to investigate the effects of a 2-year creatine supplementation protocol on bone mass in postmenopausal women.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 200
Inclusion Criteria
- healthy postmenopausal women
- T-score at lumbar spine, or femoral neck or total femur of between -1SD and -2.5SD
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Exclusion Criteria
- drugs or dietary supplements that may affect bone metabolism (e.g., bisphosphonates, AINEs, hormone replacement therapy, calcium, vitamin D, creatine supplementation)
- low BMI (< 18.5 Kg/m2).
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo dextrose (placebo) - Creatine supplementation Creatine supplementation -
- Primary Outcome Measures
Name Time Method bone mineral density (BMD) 12 and 24 months
- Secondary Outcome Measures
Name Time Method bone microarchitecture 12 and 24 months history of falls 24 months muscle function 12 and 24 months laboratory parameters 12 and 24 months bone markers 12 and 24 months will include CTX and P1NP
lean mass 12 and 24 months
Trial Locations
- Locations (1)
University of Sao Paulo - School of Medicine
🇧🇷Sao Paulo, Brazil