Efficacy of intravenous lidocaine infusion for postoperative quality of recovery in laparoscopic gynecological surgery : A triple-blind, randomized controlled trial

Phase 3

• Conditions: Quality of recoveryPostoperative painPostoperative nausea and vomiting; Intravenous lidocaine infusion; Quality of recovery; Laparoscopic gynecological surgery

• Registration Number: TCTR20240708004
• Lead Sponsor: Rajavithi Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-08
• Last Update Posted: 19 August 2024
• Study Completion: 2025-06-30

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: Female
• Target Recruitment: 64

Inclusion Criteria

1. Patients who scheduled for elective laparoscopic gynecological surgery for benign diseases
2. ASA physical status 1-2

Exclusion Criteria

1. Pregnancy
2. Body weight < 40 kg or BMI > 35 kg/m2
3. History of local anesthetic allergy
4. History of cardiac arrhythmia
5. Cirrhosis or elevated AST or ALT >/= 2x of normal upper limit
6. GFR </= 60 ml/min/1.73m2
7. Neurological disease
8. NSAID or sulfa drugs allergy
9. History of GI bleeding or peptic ulcer
10. Regular use of analgesics
11. Unable to fully understand Thai and access questionnaire and pain rating

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quality of recovery 24 hours after surgery Thai QoR-35 score

Secondary Outcome Measures

Name	Time	Method
Total 24-hour opioid consumption During 24 hours after surgery Record dose in milligram,Postoperative pain PACU, 4,8,12,24 hours after surgery Numeric rating scale,Postoperative nausea and vomiting During 24 hours after surgery Record number of times required anti-emetic drugs,Sedation Arrival time at PACU and 1 hour after surgery Ramsay sedation score